超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
精品一区二区在线播放,在线观看日本高清二区,国产操人视频
首頁 > 產品中心 > 一抗 > 產品信息
PTPN11 Rabbit pAb (bs-25352R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-25352R
英文名稱 PTPN11 Rabbit pAb
中文名稱 酪氨酸蛋白磷酸酶非受體型 11抗體
別    名 PTN11_HUMAN; Tyrosine-protein phosphatase non-receptor type 11; PTP2C; SHPTP2; EC:3.1.3.48; Protein-tyrosine phosphatase 1D(PTP-1D); Protein-tyrosine phosphatase 2C(PTP-2C); SH-PTP2(SHP-2; Shp2); SH-PTP3; protein tyrosine phosphatase non-receptor type 11; CFC; NS1; JMML; BPTP3; PTP2C; METCDS;  
研究領域 腫瘤  細胞生物  信號轉導  細胞凋亡  轉錄調節因子  激酶和磷酸酶  細胞分化  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human,Mouse (predicted: Rat,Pig,Sheep,Cow,Chicken,Horse)
產品應用 IHC-P=1:100-500,IHC-F=1:400-800,IF=1:100-500,Flow-Cyt=1ug/Test
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 68 kDa
檢測分子量
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PTPN11: 271-370/593 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Function:
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

Subunit:
Interacts with phosphorylated LIME1 and BCAR3. Interacts with SHB and INPP5D/SHIP1. Interacts with MILR1 (tyrosine-phosphorylated). Interacts with FLT1 (tyrosine-phosphorylated), FLT3 (tyrosine-phosphorylated), FLT4 (tyrosine-phosphorylated), KIT and GRB2. Interacts with PDGFRA (tyrosine phosphorylated). Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). Interacts with PTPNS1 and CD84. Interacts with phosphorylated SIT1 and MPZL1. Interacts with FCRL3, FCRL4, FCRL6 and ANKHD1. Interacts with KIR2DL1; the interaction is enhanced by ARRB2. Interacts with GAB2. Interacts with TERT; the interaction retains TERT in the nucleus. Interacts with PECAM1 and FER. Interacts with EPHA2 (activated); participates in PTK2/FAK1 dephosphorylation in EPHA2 downstream signaling. Interacts with ROS1; mediates PTPN11 phosphorylation. Interacts with PDGFRB (tyrosine phosphorylated); this interaction increases the PTPN11 phosphatase activity.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Widely expressed, with highest levels in heart, brain, and skeletal muscle.

Post-translational modifications:
Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.

DISEASE:
Phosphorylated on Tyr-546 and Tyr-584 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated upon activation of the receptor-type kinase PDGFRA (By similarity). Phosphorylated by activated PDGFRB.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
Contains 2 SH2 domains.
Contains 1 tyrosine-protein phosphatase domain.

SWISS:
Q06124

Gene ID:
5781

Database links:

Entrez Gene: 5781 Human

Entrez Gene: 19247 Mouse

Entrez Gene: 25622 Rat

Omim: 176876 Human

SwissProt: Q06124 Human

SwissProt: P35235 Mouse

SwissProt: P41499 Rat

Unigene: 506852 Human

Unigene: 474046 Mouse

Unigene: 8681 Mouse

Unigene: 98209 Rat



激酶和磷酸酶(Kinases and Phosphatases)
SHP2(SH-PTP2)參與多種細胞內信號傳導 如MAP kinase、 PI3k等途徑,SHP2也是許多其他原癌基因信號通路的重要組成部分,在細胞的增殖及分化等過程扮演重要的角色.
產品圖片
Paraformaldehyde-fixed, paraffin embedded (mouse ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PTPN11) Polyclonal Antibody, Unconjugated (bs-25352R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Blank control(black line):HepG2. Primary Antibody (green line): Rabbit Anti-PTPN11 antibody (bs-25352R) Dilution:1ug/Test; Secondary Antibody(white blue line): Goat anti-rabbit IgG-AF488 Dilution: 0.5ug/Test. Isotype control(orange line): Normal Rabbit IgG Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 90% ice-cold methanol for 20 min at -20℃, The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 老女人性生交大片免费 | 好好的日在线视频观看 | 国产一级片免费 | 成人精品三级 | www.成人18啪影院.com | 日本黄色免费在线观看 | 穿书自救指南2樱花动漫免费观看 | 黑人玩弄人妻中文在线 | 成人一级黄色毛片 | 成片人免费观看一级A片 | 国产成人无码精品久久久小说 | 久久二区视频 | 99在线精品视频免费观看软件 | 国产乱人伦偷精品视频 | 视频一区二区三区免费观看 | 成人性视频免费网站在线 | 一区二区三区午夜视频 | 国产欧美一区二区三区精品酒店 | 亚洲AV中文无码乱人伦在线R▽ | 欧美高清一区 | 三及片日本 | 欧美黑人又粗又大又爽免费 | 色99之美女主播在线视频 | 18以下岁禁止1000部免费 | gay男男自慰免费播放 | 伊人中文字幕无码专区 | 国产精品无码A∨精品影院 女人体1963免费观看视频 | 二三区视频 | 精品欧洲AV无码一区二区三区 | a级毛片毛片免费观看久潮 国产在线视频不卡一区二区三区 | 中国农村熟妇性视频 | 国产综合色产在线精品 | 国产精品JK白丝AV网站 | 国产自在自线午夜精品视频 | 欧美精品久久久久久久久老牛影院 | 香港aa三级久久三级 | 99草在线 | 视频免费1区二区三区 | 网曝门国产一区二区三区四区 | 成人国产精品入口免费视频 | 精品一区二区久久久久 |