| 產(chǎn)品編號(hào) | bsm-63170R |
| 英文名稱 | phospho-Paxillin (Y118) Recombinant Rabbit mAb |
| 中文名稱 | 磷酸化樁蛋白Paxillin重組兔單抗 |
| 別 名 | Paired box protein Pax 1; PAX 1; PAX1; Paxillin alpha; Paxillin; PXN; PXN protein. |
| 抗體來(lái)源 | Rabbit |
| 克隆類型 | Recombinant |
| 克 隆 號(hào) | 7A7 |
| 交叉反應(yīng) | Human,Mouse,Rat |
| 產(chǎn)品應(yīng)用 | WB=1:1000-1:2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 65 kDa |
| 檢測(cè)分子量 | 68 |
| 性 狀 | Liquid |
| 免 疫 原 | A synthesized peptide derived from human Paxillin around the phosphorylation site of Y118: HV-pY-SF |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 緩 沖 液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
| 保存條件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 |
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. SWISS: P49023 Gene ID: 5829 Paxillin是一種分子量為68KDa的局部粘附蛋白，參與腫瘤細(xì)胞的粘附與轉(zhuǎn)移。主要用于各種惡性腫瘤的研究。Paxillin 蛋白是胞外基質(zhì)細(xì)胞粘附（粘著斑）位點(diǎn)上肌動(dòng)蛋白-膜附著的細(xì)胞骨架蛋白。Paxillin 在整合蛋白的信號(hào)傳導(dǎo)中起著非常重要的作用，整合蛋白介導(dǎo)的細(xì)胞骨架的再組織需要，paxillin 酪氨酸殘基的磷酸化。Paxillin 被粘著斑激酶 (FAK)在其118位的酪氨酸殘基處磷酸化。已經(jīng)證明，paxillin 118位和31位兩個(gè)酪氨酸的磷酸化對(duì)于MM1癌細(xì)胞的遷移是重要的。 |
