超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
亚洲乱码国产乱码精品精可以看,久久人人爽亚洲精品天堂,精品久久精品久久
首頁 > 產品中心 > 一抗 > 產品信息
ZO-1 Rabbit pAb (bs-34023R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
大包裝/詢價

產品編號 bs-34023R
英文名稱 ZO-1 Rabbit pAb
中文名稱 胞質緊密粘連蛋白1/閉鎖小帶蛋白1抗體
別    名 ZO1_HUMAN; Tight junction protein ZO-1; TJP1; Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1;  
Specific References  (3)     |     bs-34023R has been referenced in 3 publications.
[IF=8.039] Yifan Zhu. et al. Discovery of Selective P2Y6R Antagonists with High Affinity and In Vivo Efficacy for Inflammatory Disease Therapy. J MED CHEM. 2023;XXXX(XXX):XXX-XXX  WB ;  Mouse.  
[IF=6.073] Huang Li. et al. Gut microbiota decreased inflammation induced by chronic unpredictable mild stress through affecting NLRP3 inflammasome. FRONT CELL INFECT MI. 2023 May;13:558  WB ;  Rat.  
[IF=5.195] Shan Luo. et al. Application of omics technology to investigate the mechanism underlying the role of San Hua Tang in regulating microglia polarization and blood-brain barrier protection following ischemic stroke. J ETHNOPHARMACOL. 2023 May;:116640  WB ;  Rat.  
研究領域 細胞生物  免疫學  信號轉導  細胞粘附分子  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Human
產品應用 WB=1:500-2000,Flow-Cyt=1μg/Test,ICC/IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 191 kDa
檢測分子量
細胞定位 細胞漿 細胞膜 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZO-1 
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antib
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Function:
The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.

Subunit:
Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with HSPA4 and KIRREL1. Homodimer, and heterodimer with TJP2/ZO-2 and TJP3/ZO-3. Interacts with OCLN, CALM, claudins, CGN/cingulin, CXADR, GJA12, GJD3 and UBN1. Interacts (via ZU5 domain) with CDC42BPB and MYZAP. Interacts (via PDZ domain) with GJA1.

Subcellular Location:
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction. Cell junction. Cell junction, gap junction. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact.

Tissue Specificity:
The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.

Post-translational modifications:
Phosphorylated. Dephosphorylated by PTPRJ.

Similarity:
Belongs to the MAGUK family.
Contains 1 guanylate kinase-like domain.
Contains 3 PDZ (DHR) domains.
Contains 1 SH3 domain.
Contains 1 ZU5 domain.

SWISS:
Q07157

Gene ID:
7082

Database links:
胞質緊密粘連蛋白1(ZO-1)是多結構域蛋白家族膜結合鳥苷酸激酶的家族成員,在緊密連接蛋白的組成成分中起到對組織分化和器官形成方面起較重要的作用。ZO-1在包括腎、胎盤、血腦屏障等許多組織都有不同的表達,可與緊密連接上的很多跨膜蛋白相互作用。也有學者認為:ZO-1的改變與細胞通透性的增加有關。

產品圖片
25 ug total protein per lane of various lysates (see on figure) probed with ZO-1 polyclonal antibody, unconjugated (bs-34023R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
The MCF-7 (H) cells were incubated in 5%BSA to block non-specific protein-protein interactions (30 min at r.t.). Primary Antibody (green): Rabbit Anti-ZO-1 antibody (bs-34023R): 1 μg/10^6 cells; Secondary Antibody (white blue): Goat anti-Rabbit IgG-BF488 (bs-60295G-BF488): 1 μg/test. Isotype Control (orange): Rabbit IgG (bs-0295P). Blank control (black): PBS. Acquisition of 20,000 events was performed.
The MCF-7 (H) cells were incubated in 5%BSA to block non-specific protein-protein interactions (30 min at r.t.). Primary Antibody (green): Rabbit Anti-ZO-1 antibody (bs-34023R): 1 μg/10^6 cells; Secondary Antibody (white blue): Goat anti-Rabbit IgG-BF488 (bs-60295G-BF488): 1 μg/test. Isotype Control (orange): Rabbit IgG (bs-0295P). Blank control (black): PBS. Acquisition of 20,000 events was performed.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 色青青草原桃花久久综合 | 久久综合色鬼综合色 | 久碰香蕉线视频在线观看视频 | 亚洲精品无码一区二区四区 | 国产又粗又猛又爽的免费网站 | 无码人妻精品一区二区三区夜夜嗨 | 精品国产三级 | 欧美一级视频播放 | 91麻豆精品国产91久久久使用方法 | 看色网站 | 大地资源网免费观看高清 | 亚洲精品乱码久久久久久麻豆不卡 | 国产精品国产三级国产普通话一 | 亚洲综合麻豆 | 国产一级不卡视频 | 日本熟妇人妻xxxxx视频 | 欧美精品在线观看一区 | 日本六九视频69jzz | 在线播放偷拍一区精品小说 | 国产精选第一页 | 国产精品视频免费网站 | 久久国产婷婷国产香蕉 | 成年视频在线播放 | 无码中文日本精品一区 | 欧美不卡三区 | 免费无套内谢少妇毛片A片软 | 日本久久久久久级做爰片 | 99热99在线 | 91爱啪| 91视频91自| 91在线视频导航 | 在线观看免费视频91 | 中国成人免费视频 | 男女视频一区二区 | 国产精品亚洲АV无码播放 闷骚的老熟女人15P | 欧美成人精品第一区 | 久久福利免费视频 | 91麻豆国产福利在线观看宅福利 | 国产麻豆乱子伦午夜视频观看 | 国产亚洲影视在线视频播放 | 免费在线看一区 |