超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日韩一日,国产亚洲色欲色一色WWW,成人免费版
首頁 > 產品中心 > 一抗 > 產品信息
IL-4R Rabbit pAb (bs-41425R)  
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包裝/詢價

產品編號 bs-41425R
英文名稱 IL-4R Rabbit pAb
中文名稱 白細胞介素4受體抗體
別    名 CD124; IL 4R alpha; IL-4 receptor subunit alpha; IL-4-binding protein; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4-BP; Il4r; IL4R nirs variant 1; IL4RA; IL4RA_MOUSE; Interleukin 4 receptor alpha chain; Interleukin 4 receptor; sIL4Ralpha/prot; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; Soluble interleukin-4 receptor subunit alpha  
研究領域 細胞生物  免疫學  細胞膜受體  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
克 隆 號
交叉反應 Mouse (predicted: Rat)
產品應用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理論分子量 88 kDa
檢測分子量
細胞定位 細胞膜 分泌型蛋白 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 Recombinant mouse IL-4R : 26-233/810 <Extracellular>
亞    型 IgG
純化方法 affinity purified by Protein A
緩 沖 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
產品介紹 This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammmation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2.
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.

Subunit:
The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (By similarity). Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling. Subcellular Location : Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted.

Tissue Specificity:
Isoform 1 and isoform 2 are highly expressed in activated T-cells.

Post-translational modifications:
On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.
The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.

Similarity:
Belongs to the type I cytokine receptor family. Type 4 subfamily.
Contains 1 fibronectin type-III domain.

SWISS:
P16382

Gene ID:
16190

Database links:

Entrez Gene: 3566 Human

Omim: 147781 Human

SwissProt: P24394 Human

Unigene: 513457 Human



IL4R實際分子量約140 kDa. (J. Exp. Med. 2015 Vol. 212 No. 1 73–91;Cancer Res 2014;74:4329-4340)(Jim 2019-03-27);
產品圖片
Sample: Lane 1: Testis (Mouse) Lysate at 40 ug Lane 2: NIH/3T3 (Mouse) Cell Lysate at 30 ug Primary: Anti-IL-4R (bs-41425R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 140 kD Observed band size: 140 kD
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 四虎影视久久久免费 | 国产55页 | 久热中文字幕在线精品观 | 免费无码黄在线观看www | 午夜久久久久久久久 | 在线观看免费毛片 | 欧美极品少妇xxxx | 在线欧美色 | 亚洲综合熟女久久久30p | 91传媒麻豆激情在线观看 | 欧美一区二区视频17c | 一区二区欧洲三区 | 日韩av免费在线播放 | 韩国av片永久免费 | 欧日韩精品 | 91丨国产丨蚪窝海角社区 | 4kmoms丰满hdfilm | 国产高清在线精品二区 | 国产精品AV一区二区三区不卡蜜 | 亚洲精品深夜AV无码一区二区 | 久久www免费人成看片爱潮 | 久久青草网站 | 成人深夜在线 | 久久97精品久久久久久久不卡 | 日本成a人片在线观看日本 久久婷婷五月综合色国产免费观看 | 伊人中文字幕无码专区 | 国产乱码精品一品二品 | 2019国产精品| 酒色影院| 欧美一级一级一级 | 在线成人免费观看视频 | 欧美亚一区二区 | 自拍偷拍专区 | 日本免费一区二区三区最新 | 欧美一区二区二区 | 黑人床戏 | 人妻激情偷乱视频一区二区三区 | 亚洲乱码国产乱码精品精的特点 | 里番全彩爆乳女教师 | 韩国av在线免费观看 | 亚洲一区二区三区精品动漫 |