| 產(chǎn)品編號(hào) | IHC0473R |
| 英文名稱 | Rat Vinculin Ready-To-Use IHC Kit |
| 中文名稱 | 大鼠粘著斑蛋白（內(nèi)參）即用型免疫組化試劑盒 |
| 別 名 | 9430097D22; AA571387; AI462105; AW545629; CMD1W; CMH15; HEL114; MV; MVCL; VCL; Metavinculin; Vinculin |
| 克 隆 號(hào) | |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15. SWISS: P18206 Gene ID: 7414 |
| 產(chǎn)品圖片 |
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Immunohistochemical analysis of paraffin embedded rat colon tissue slide using IHC0473R (Rat Vinculin IHC Kit).
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