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Rabbit Anti-Integrin alpha 5/AP Conjugated antibody (bs-0567R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0567R-AP
英文名稱 Rabbit Anti-Integrin alpha 5/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的整合素α5抗體
別    名 Integrin alpha-5 light chain; Alpha 5 beta 1; CD49 antigen-like family member E; CD49e; ECMRVI; Fibronectin Receptor alpha; Fibronectin receptor alpha subunit; Fibronectin receptor, alpha subunit; FNR; FNRA; gpIc/IIa; Integrin alpha 5 (fibronectin receptor alpha); Integrin alpha 5; Integrin alpha F; Integrin alpha-5; Integrin alpha-F; Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITGA5; Very late Activation Antigen 5; Very Late Activation Protein 5 alpha; Very late activation protein 5, alpha subunit; VLA5; VLA5A; ITA5_HUMAN; Integrin α5; Integrin-α5.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  干細(xì)胞  細(xì)胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 110kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Integrin alpha-5 light chain
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

Function:
CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling.

Subunit:
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with RAB21 and COMP. Interacts with HIV-1 Tat.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.

Database links:

Entrez Gene: 3678 Human

Entrez Gene: 16402 Mouse

Entrez Gene: 315346 Rat

Omim: 135620 Human

SwissProt: P08648 Human

SwissProt: P11688 Mouse

Unigene: 505654 Human

Unigene: 16234 Mouse

Unigene: 100796 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ITG-α5粘附分子整合素α5也是細(xì)胞粘附分子的超家族成員,廣泛分布于細(xì)胞表面和細(xì)胞外基質(zhì)的糖蛋白,不僅介導(dǎo)細(xì)胞與細(xì)胞或細(xì)胞與基質(zhì)之間的連接,而且參與細(xì)胞間的信號轉(zhuǎn)導(dǎo),細(xì)胞的生長移行,腫瘤的轉(zhuǎn)移浸潤,免疫炎性反應(yīng),血管生成等一系列的生理和病理過程。
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