| 產(chǎn)品編號(hào) | bs-1356R-AP |
| 英文名稱(chēng) | Rabbit Anti-Integrin Alpha V + Beta 5/AP Conjugated antibody |
| 中文名稱(chēng) | 堿性磷酸酶（AP）標(biāo)記的整合素αVβ5抗體 |
| 別 名 | alpha 5; alpha polypeptide; CD49e; CD51; fibronectin receptor; FNRA; Integrin alpha V; Integrin beta 5; ITGA5; ITGAV; ITGB5; VLA5A; VNRA. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢(xún)價(jià) |
| 說(shuō) 明 書(shū) | 100ul |
| 研究領(lǐng)域 | 細(xì)胞生物 干細(xì)胞 細(xì)胞粘附分子 |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, ) |
| 產(chǎn)品應(yīng)用 | IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 88/121kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Integrin beta 5 and Integrin alpha V C-terminus |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumour cells. ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. Subcellular Location: Cell Membrane Database links: Entrez Gene: 395142 Chicken Entrez Gene: 396420 Chicken Entrez Gene: 3685 Human Entrez Gene: 3693 Human Omim: 147561 Human Omim: 193210 Human SwissProt: P26008 Chicken SwissProt: P06756 Human SwissProt: P18084 Human Unigene: 436873 Human Unigene: 536663 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 整合素αVβ3、αVβ5是特異性表達(dá)在血管內(nèi)皮細(xì)胞表面的粘附因子，在介導(dǎo)內(nèi)皮細(xì)胞和ECM相互接觸中起作用。 整合素（integrin）分布廣泛，屬于細(xì)胞黏附分子家族。經(jīng)研究發(fā)現(xiàn)整合素可以調(diào)節(jié)細(xì)胞-細(xì)胞、細(xì)胞-細(xì)胞外基質(zhì)(extracellular matrix，ECM〕間的黏附。整合素所介導(dǎo)的腫瘤細(xì)胞與ECM間的相互作用影響腫瘤的發(fā)生、增殖、侵襲和轉(zhuǎn)移到其他組織的能力。 |
