超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日本超黄视频,国产又粗又大又硬点视频,成人H无码动漫超W网站
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Beclin 1/Cy5.5 Conjugated antibody (bs-1353R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1353R-Cy5.5
英文名稱 Rabbit Anti-Beclin 1/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標記的Bcl-2同源結構域蛋白抗體
別    名 Beclin-1; ATG6; beclin1; VPS30; Beclin 1 like protein 1; 4921513J16Rik; 5430417M23Rik; ATG6; BECLIN 1; BECN1; MGC6843; BECN1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  神經生物學  細胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, Rabbit, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BECN1 (236-280aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons.

Function:
Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.

Subunit:
Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy. Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts with PIK3CB. Interacts with DAPK1. Interacts with human cytomegalovirus/HHV-5 protein TRS1.

Subcellular Location:
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy.
Ubiquitinated. Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes.

Similarity:
Belongs to the beclin family.

Database links:

Entrez Gene: 8678 Human

Entrez Gene: 56208 Mouse

Entrez Gene: 114558 Rat

Omim: 604378 Human

SwissProt: Q14457 Human

SwissProt: O88597 Mouse

SwissProt: Q91XJ1 Rat

Unigene: 716464 Human

Unigene: 178947 Mouse

Unigene: 2776 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

BECN1是一種分子質量為60KDa的蛋白質, 它能與細胞凋亡抑制劑Bcl-2相互作用, 減少中樞神經系統的凋亡,參與PI3K復合物的組成和自噬體的形成。主要表達在胞質。抑癌基因beclin 1通過自噬作用來調節細胞生長。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 色综合激情无码中文字幕 | 黄频视频在线观看 | 在线成人免费网站 | 中文无码熟妇人妻AV在线 | 好吊妞人成视频在线观看强行 | 国产精品成人久久久久久久 | 日韩黄色 | 国内精品久久久久久久影视麻生 | 91av国产精品 | 久久久久久1 | 久久夜精品va视频免费观看 | 国产精品免费久久久久影院仙踪林 | 中文成人无码精品久久久不卡 | 在线偷窥| 国产人成视频在线视频 | 911亚洲精品第一 | 成人AV导航 | 伊人久久久精品区aaa片 | 国产成人综合视频在线 | 国产精品丝袜肉丝出水 | 久草视频在 | 一个人看的www视频免费观看 | 成人一区二区三区四区 | 国产成年女人毛片80s网站 | 精品一区二区三区四区视频 | avtom影院永久地址 | 国产精品国语版在线观看 | 天天综合亚洲色在线精品 | 日韩av一区二区三区美女毛片 | 成人福利免费观看 | 婷婷激情综合色五月久久图片 | 4虎永久 | 亚洲色无色A片一区二区 | 91免费播放人人爽人人快乐 | 国产精品久久国产三级国电话系列 | 视频一区二区无码制服师生 | 成人区一区二区三区 | 福利社午夜影院 | 一本久道在线视频 | 欧美一级淫片a免费播放口 日韩免费一级 | 欧美日韩国产一中文字不卡 |