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Rabbit Anti-Bassoon/BF488 Conjugated antibody (bs-0275R-BF488)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0275R-BF488
英文名稱 Rabbit Anti-Bassoon/BF488 Conjugated antibody
中文名稱 BF488標記的鋅指蛋白231抗體
別    名 Bassoon; BSN; KIAA0434; Neuronal double zinc finger protein; Presynaptic cytomatrix protein; Protein bassoon; Zinc finger protein 231; ZNF 231; ZNF231; Neuronal double zinc finger protein; Zinc-finger protein 231; BSN_HUMAN; ZNF 231.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  鋅指蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 432kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BSN (2901-3000aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008].

Function:
Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses.

Subunit:
Interacts with ERC2/CAST1, RIMS1 and UNC13A. Part of a complex consisting of ERC2, RIMS1 and BSN.

Subcellular Location:
Cytoplasm. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Localized to the active zone of presynaptic density.

Tissue Specificity:
Exclusively expressed in brain.

Post-translational modifications:
Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization.

Database links:

Entrez Gene: 8927 Human

Entrez Gene: 12217 Mouse

Entrez Gene: 29138 Rat

Omim: 604020 Human

SwissProt: O43161 Human

SwissProt: Q9UPA5 Human

SwissProt: O88737 Mouse

SwissProt: O88778 Rat

Unigene: 194684 Human

Unigene: 20425 Mouse

Unigene: 29999 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

鋅指蛋白是80年代中期發現的一類DNA結合蛋白,在真核生物中,鋅指蛋白可能是最大的一類DNA結合蛋白,并且由鋅指蛋白調控基因表達是發育和其他過程的一個非常普遍的現象。在最近的幾年中,發現某些鋅指蛋白對肌肉的發育具有重要的調節作用。
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