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Mouse Anti-HBsAg(H2F4)/FITC Conjugated antibody (bsm-2024M-FITC)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bsm-2024M-FITC
英文名稱 Mouse Anti-HBsAg(H2F4)/FITC Conjugated antibody
中文名稱 FITC標記的人乙型肝炎表面抗原單克隆抗體(檢測)
別    名 Hepatitis B Virus Surface Antigen; HBsAg; HBV major surface antigen; HBV surface antigen; Hepatitis B Virus major surface antigen; Major surface antigen; S; HBSAG_HBVC5.  
Journal
PMID
IF
Application
[IF=14.679] Yu Liu. et al. MAIT Cell Dysregulation Correlates with Conjugated Bilirubin Level in Chronic Hepatitis B Virus Infection. 2020 Oct 20  IF ;  Human.  
[IF=4.539] Tan X et al. Elevated Hepatic CD1d Levels Coincide with Invariant NKT Cell Defects in Chronic Hepatitis B Virus Infection.J Immunol. 2018 May 15;200(10):3530-3538.  IF ;  Human.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 免疫學  細菌及病毒  
抗體來源 Mouse
克隆類型 Monoclonal
克 隆 號 H2F4
交叉反應
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 Human Hepatitis B Surface Antigen protein
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Hepatitis B Virus Surface Antigen, Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase.

Function:
The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.

Subunit:
Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion.

Subcellular Location:
Virion membrane.

Post-translational modifications:
Isoform M is N-terminaly acetylated at a ratio of 90%, and N-glycosylated at the pre-S2 region.
Myristoylated.

Similarity:
Belongs to the orthohepadnavirus major surface antigen family.

Database links:

Entrez Gene: 2828293 Hepatitis B virus

Entrez Gene: 944569 Hepatitis B virus

SwissProt: P03138 Hepatitis B virus

SwissProt: P03140 Hepatitis B virus

SwissProt: P03141 Hepatitis B virus

SwissProt: Q81157 Hepatitis B virus

SwissProt: Q81158 Hepatitis B virus

SwissProt: Q81159 Hepatitis B virus

SwissProt: Q81160 Hepatitis B virus



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

人乙型肝炎表面抗原抗體
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