超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
超碰97人人人人人蜜桃,一区二区三区精品视频免费播放,欧美内射RAPE视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-Bcl-xL (Ser62)/AP Conjugated antibody (bs-1337R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1337R-AP
英文名稱 Rabbit Anti-phospho-Bcl-xL (Ser62)/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的磷酸化Bcl-xL(Ser62)抗體
別    名 Apoptosis regulator Bcl X; BclX; Bcl-X; Bcl 2 like 1; Bcl 2 like 1 protein; Bcl xL; BCL X/L; BCL XL/S; Bcl xS; Bcl2 like1; BCL2-related gene; BCL2-related protein, long isoform, included; BCLXL, included; BCL2-related protein, short isoform, included; BCLXS, included; BCL2L; Bclx; DKFZp781P2092; MGC113803; MGC99998; B2CL1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  神經生物學  信號轉導  細胞凋亡  新陳代謝  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產品應用 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Bcl-xL around the phosphorylation site of Ser62
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008].

Function:
Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
Isoform Bcl-X(S) promotes apoptosis.

Subunit:
Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with DMN1L; the interaction stimulates the GTPase activity of DMN1L in synapses and increases the number of axonal mitochondria and the size and number of synaptic vesicle clusters. Interacts with BAD and BBC3. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Interacts (isoform Bcl-X(L)) with BAX (isoform Sigma). Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2.

Subcellular Location:
Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, centrosome. Note=Mitochondrial membranes and perinuclear envelope. Localizes to the centrosome when phosphorylated at Ser-49.

Tissue Specificity:
Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Post-translational modifications:
Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis.

Similarity:
Belongs to the Bcl-2 family.

Database links:

Entrez Gene: 598 Human

Entrez Gene: 12048 Mouse

Entrez Gene: 24888 Rat

Omim: 600039 Human

SwissProt: Q07817 Human

SwissProt: Q64373 Mouse

SwissProt: P53563 Rat

Unigene: 516966 Human

Unigene: 238213 Mouse

Unigene: 10323 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Bcl XL蛋白是Bcl蛋白家族的成員之一,是細胞中抑制細胞凋亡的重要分子之一,Bcl-XL是結構上與Bcl-2具有43%同源性的蛋白,與Bcl-2的作用相同,可抑制細胞凋亡,在腫瘤的發生和發展中起重要作用。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 成人做爽爽爽爽免费国产软件 | 国产在线精品免费AAA片 | 久久精品亚 | 成年人在线免费看 | 国产AV无码专区亚洲AV潘金链 | 国产亚洲精品中文字幕 | 欧美日韩a级片 | 亚洲狠狠做深爱婷婷影院 | 日日夜夜操操操操 | 日韩中文免费 | 五十路六十路老熟妇a片 | 五月丁香六月狠狠爱综合 | 欧美成人久久久 | 骚妇BB双飞插| 国产福利视频一区 | 国产欧美久久久精品影院 | 亚洲国产一区二区三区在线观看 | 国产午夜无码片在线观看 | 一级一级一片在线观看 | 在线观看自拍 | 一本久久a久久精品合男女 韩国成人免费视频 | 亚洲中文字幕在线网址 | 女人体1963免费观看视频 | 狠狠爱无码一区二区三区 | 成人无码www免费视频嘿嘿软件 | 黄色的视频免费观看 | www.youjizz日本 | 国产精品无码A∨精品影院 女人体1963免费观看视频 | 免费色播 | 国产乡下妇女三片 | 成人国产精品久久久春色 | 成年女人永久免费观看视频 | av成人福利| 久久久久久女乱国产 | 东京亚洲区卡不 | 成人不卡免费视频 | 免费一级淫片aaa片毛片a级 | 国产日产欧洲无码视频无遮挡 | 久久精品亚洲精品国产欧美 | av中文字幕免费在线观看 | 无码AV无码一区二区 |