超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
av性网站,欧美日本一,亚洲av无码专区亚洲av不卡
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-Bcl-xL (Ser62)/BF350 Conjugated antibody (bs-1337R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1337R-BF350
英文名稱 Rabbit Anti-phospho-Bcl-xL (Ser62)/BF350 Conjugated antibody
中文名稱 BF350標記的磷酸化Bcl-xL(Ser62)抗體
別    名 Apoptosis regulator Bcl X; BclX; Bcl-X; Bcl 2 like 1; Bcl 2 like 1 protein; Bcl xL; BCL X/L; BCL XL/S; Bcl xS; Bcl2 like1; BCL2-related gene; BCL2-related protein, long isoform, included; BCLXL, included; BCL2-related protein, short isoform, included; BCLXS, included; BCL2L; Bclx; DKFZp781P2092; MGC113803; MGC99998; B2CL1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  神經生物學  信號轉導  細胞凋亡  新陳代謝  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 26kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Bcl-xL around the phosphorylation site of Ser62
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008].

Function:
Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
Isoform Bcl-X(S) promotes apoptosis.

Subunit:
Homodimer. Isoform Bcl-X(L) forms heterodimers with BAX, BAK or BCL2. Heterodimerization with BAX does not seem to be required for anti-apoptotic activity. Interacts with BCL2L11. Interacts with DMN1L; the interaction stimulates the GTPase activity of DMN1L in synapses and increases the number of axonal mitochondria and the size and number of synaptic vesicle clusters. Interacts with BAD and BBC3. Interacts (isoform Bcl-X(L)) with SIVA1 (isoform 1); the interaction inhibits the anti-apoptotic activity. Interacts with BECN1 and PGAM5. Interacts (isoform Bcl-X(L)) with BAX (isoform Sigma). Isoform Bcl-X(L) interacts with IKZF3. Interacts with HEBP2.

Subcellular Location:
Mitochondrion membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, centrosome. Note=Mitochondrial membranes and perinuclear envelope. Localizes to the centrosome when phosphorylated at Ser-49.

Tissue Specificity:
Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.

Post-translational modifications:
Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis.

Similarity:
Belongs to the Bcl-2 family.

Database links:

Entrez Gene: 598 Human

Entrez Gene: 12048 Mouse

Entrez Gene: 24888 Rat

Omim: 600039 Human

SwissProt: Q07817 Human

SwissProt: Q64373 Mouse

SwissProt: P53563 Rat

Unigene: 516966 Human

Unigene: 238213 Mouse

Unigene: 10323 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Bcl XL蛋白是Bcl蛋白家族的成員之一,是細胞中抑制細胞凋亡的重要分子之一,Bcl-XL是結構上與Bcl-2具有43%同源性的蛋白,與Bcl-2的作用相同,可抑制細胞凋亡,在腫瘤的發生和發展中起重要作用。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 日韩天堂网 | 中文字幕精品久久一区二区三区 | 中国女人真人一级毛片 | 亚洲vs天堂 | 亚洲国产精品久久久久婷婷老年 | 亚洲乱码无人区卡1卡2卡3 | 欧洲乱码伦视频免费国产 | 伊人黄色软件 | 一本色道精品久久一区二区三区 | 黄网免费观看 | 一区二区三区四区不卡在线 | 亚洲激情av在线 | 久久无码色综合中文字幕 | 欧美寡妇xxxx黑人猛交玩 | 国产成年女人毛片80s网站 | 大香伊人久久精品一区二区 | 色噜噜狠狠成人网p站 | 成人做爽爽爽爽免费国产软件 | 操bb影院| 无码伊人久久大杳蕉中文无码 | 一级片在线免费观看视频 | 国产亚洲日本精品无码 | 欧美成年人影院 | 人妻忍着娇喘被中进中出视频 | 99国产精品久久久久久久日本竹 | 9999精品成人免费毛片在线看 | 久久久久国产一区二区三区不卡 | 男人的天堂Aⅴ在线无码 | 午夜精品美女自拍福到在线 | 日本黄色xxxx| 高清国产精品人妻一区二区 | 男人女人一边躁一边爽 | 尤物久久av一区二区三区亚洲 | 精品日韩在线一区 | 日韩不卡手机视频在线观看 | 中文字幕第一页卡通动漫在线 | 制服丝袜国产在线无码 | 日韩福利影院 | 激情五月亚洲色图 | 婷婷久久丁香 | 欧美亚洲视频一区二区 |