超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
久久久久久久一级,天天摸天天添人人澡,国产精品动漫一区二区
Rabbit Anti-TPA/PE-Cy5 Conjugated antibody (bs-1545R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1545R-PE-Cy5
英文名稱 Rabbit Anti-TPA/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的組織型纖溶酶原激活劑抗體
別    名 TPA Tissue Plasminogen Activator; Plasminogen activator tissue; Plasminogen activator tissue type; Plasminogen Activator Tissue Type Isoform 1 Preproprotein; PLAT; Reteplase; t PA; t-PA; T Plasminogen Activator; Tissue plasminogen activator (t PA); PATISS; Tissue type plasminogen activator; TPA1; AU020998; AW212668; D8Ertd2e; MGC18508; TPA_HUMAN; Tissue-type plasminogen activator; t-plasminogen activator; Alteplase; Tissue-type plasminogen activator chain B.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  神經(jīng)生物學(xué)  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28/58kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Tissue-type plasminogen activator chain B
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

Function:
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.

Subunit:
Heterodimer of chain A and chain B held by a disulfide bond. Forms a heterodimer with SERPINA5. Binds to fibrin with high affinity. This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-fold and 1000-fold, due to an increase in affinity for plasminogen. Similarly, binding to heparin increases the activation of plasminogen. Binds to annexin A2, cytokeratin-8, fibronectin and laminin. Binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1); these proteins are involved in TPA clearance. Yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation. In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold. Binds LRP1B; binding is followed by internalization and degradation.

Subcellular Location:
Secreted.

Tissue Specificity:
Synthesized in numerous tissues (including tumors) and secreted into most extracellular body fluids, such as plasma, uterine fluid, saliva, gingival crevicular fluid, tears, seminal fluid, and milk.

Post-translational modifications:
The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.
Differential cell-specific N-linked glycosylation gives rise to two glycoforms, type I (glycosylated at Asn-219) and type II (not glycosylated at Asn-219). The single chain type I glycoform is less readily converted into the two-chain form by plasmin, and the two-chain type I glycoform has a lower activity than the two-chain type II glycoform in the presence of fibrin.
N-glycosylation of Asn-152; the bound oligomannosidic glycan is involved in the interaction with the mannose receptor.
Characterization of O-linked glycan was studied in Bowes melanoma cell line.

DISEASE:
Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.

Similarity:
Belongs to the peptidase S1 family.
Contains 1 EGF-like domain.
Contains 1 fibronectin type-I domain.
Contains 2 kringle domains.
Contains 1 peptidase S1 domain.

Database links:

Entrez Gene: 5327 Human

Omim: 173370 Human

SwissProt: P00750 Human

Unigene: 491582 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

組織型纖溶酶原激活劑tPA是絲氨酸蛋白酶家族的一員,其主要的生物學(xué)功能是激活纖溶酶原轉(zhuǎn)變?yōu)槔w溶酶.
近年來經(jīng)研究表明t-PA參與循環(huán)系統(tǒng)的溶血栓過程之外,t-PA還在神經(jīng)系統(tǒng)中也發(fā)揮了重要的作用,t-PA參與了癲癇和早老型癡呆癥等神經(jīng)系統(tǒng)疾病的發(fā)生和發(fā)展,在學(xué)習(xí)和記憶等生理過程中也發(fā)揮了重要作用。
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 大地资源中文第3页 | 国产亚洲精品无 | 日产精品一区二区 | 夜夜操天天爽 | 久久不见久久见免费影院视频观看 | 国产精品666tv成人影院 | 久久国产精品-久久精品 | 国产精品久久久久久久综合 | 欧美久久久久久久 | 亚洲日韩欧美在线观看 | 久久综合色区 | 国产乱人伦真实精品视频 | gav成人免费播放器 真实国产精品视频400部 | 国产三区在线观看视频 | 中文字幕特级片 | 国产三级在线观看播放 | 伊人春色影院 | 久久久亚洲网站 | 黑人chinese中国china国产 | 天天天做夜夜夜做无码 | 亚洲女人在线观看 | 亚洲欧美高清一区二区三区 | 无码字幕av一区二区三区 | 99爱国产精品 | 在线观看免费视频一区二区 | 香蕉97人人乳视频观看 | 国产亚洲精品中文字幕 | 日韩欧美在线播放视频 | 深夜激情视频 | 9999精品成人免费毛片在线看 | 亚洲欧美成人在线 | 中文字幕av久久人妻蜜桃臀 | 少妇做爰免费视频网站裸体艺术 | 国产免费成人av | 27邪态恶动图gif喷水赞一把 | 精品久久久一二三区 | 国产视频一区二区三区四区 | 五月天色av | 亚洲精品字幕 | 狠狠操福利视频 | 91成人入口 |