超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日韩精品在线一区二区,把插八插露脸对白内射,3344永久在线观看视频免费
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-KCNMA1/BK channel/BF488 Conjugated antibody (bs-0729R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0729R-BF488
英文名稱 Rabbit Anti-KCNMA1/BK channel/BF488 Conjugated antibody
中文名稱 BF488標記的鈣激活鉀通道蛋白 α 1抗體
別    名 Maxi Potassium channel alpha; bA205K10.1; BK channel; BKCa channels; BKCA alpha; BKCA alpha subunit; BKTM; Calcium activated potassium channel subfamily M subunit alpha 1; Calcium activated potassium channel subunit alpha 1; DKFZp686K1437; Drosophila slowpoke like; hSlo; K(VCA)alpha; KCa1.1; KCNMA 1; KCNMA; KCNMA1; Large conductance calcium activated potassium channel subfamily M alpha member 1; Maxi K; Maxi K channel; MaxiK; Potassium large conductance calcium activated channel subfamily M alpha member 1; SAKCA; Slo 1; SLO alpha; SLO; Slo homolog; Slo1; Slowpoke homolog; Stretch activated Kca channel; KCMA1_HUMAN.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 神經生物學  信號轉導  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Rabbit, Sheep, )
產品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 137kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BK channel (1120-1165aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

Function:
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

Subunit:
Homotetramer.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Tissue Specificity:
Widely expressed. Except in myocytes, it is almost ubiquitously expressed.

Post-translational modifications:
Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity.

DISEASE:
Defects in KCNMA1 are the cause of generalized epilepsy and paroxysmal dyskinesia (GEPD) [MIM:609446]. Epilepsy is one of the most common and debilitating neurological disorders. Paroxysmal dyskinesias are neurological disorders characterized by sudden, unpredictable, disabling attacks of involuntary movement often requiring life-long treatment. The coexistence of epilepsy and paroxysmal dyskinesia in the same individual or family is an increasingly recognized phenomenon. Patients manifest absence seizures, generalized tonic-clonic seizures, paroxysmal nonkinesigenic dyskinesia, involuntary dystonic or choreiform movements. Onset is usually in childhood and patients may have seizures only, dyskinesia only, or both.

Similarity:
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
Contains 1 RCK N-terminal domain.

Database links:

Entrez Gene: 3778 Human

Entrez Gene: 16531 Mouse

Entrez Gene: 83731 Rat

Omim: 600150 Human

SwissProt: Q12791 Human

SwissProt: Q08460 Mouse

SwissProt: Q62976 Rat

Unigene: 144795 Human

Unigene: 343607 Mouse

Unigene: 486347 Mouse

Unigene: 30616 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

通道蛋白(Channel Protein)
該抗體主要用于細胞膜通道的研究。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 亚洲AV无码专区在线亚 | 性爱网站| 久久久久一区二区三区四区 | 免费看裸体美女脱了衣服露视频胸 | 色综合网在线 | 囯产无码大放纵视频 | 无遮挡啪啪摇乳动态图GIF | 成人国产精品免费网站 | 欧亚洲嫩模精品一区三区 | 已婚丰满少妇21P | 亚洲人在线观看视频 | 欧美精品久久久久久久久久丰满 | www.色涩涩.com | 欧美日韩久久久精品A片妖精 | 国产网曝门视频在线看 | 欧美三级欧美成人高清www | 亚洲精品狼友在线播放 | 国产精品久久丫 | 成人性生交大片免费看视 | 亚洲国产精品成人综合色 | 99久久精品免费播放 | 粉嫩玉足夹茎视频在线看 | 国产亚洲综合AA系列 | 亚洲成年人av | 久久久经典 | 国产成人综合一区 | 亚洲乱亚洲乱妇91p丰满 | 欧美亚洲国产日韩 | 国产亚洲在 | 欧美日一 | 夜夜爽日日澡人人添小说 | h肉动漫无码无修6080动漫网 | 欧洲色婷婷 | 中文字幕在线观看亚洲日韩 | 红色av社区 | 亚洲乱码日产精品bd | 爱情不设限在线观看 | 精品国产网站 | 99精品免费观看 | 国产第一福利 | 天天色成人网 |