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Rabbit Anti-BBC3/PUMA/BF488 Conjugated antibody (bs-1573R-BF488)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1573R-BF488
英文名稱 Rabbit Anti-BBC3/PUMA/BF488 Conjugated antibody
中文名稱 BF488標記的p53正向細胞凋亡調控因子抗體
別    名 PUMA; bcl-2 binding component 3; BBC 3; BBC3; BCL 2 binding component 3; BCL2 binding component 3; JFY 1; JFY1; p53 up regulated modulator of apoptosis; p53 Upregulated Modulator of Apoptosis; PUMA alpha; PUMA/JFY1; BBC3_RAT.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  細胞凋亡  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, )
產品應用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 21kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BBC3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Function:
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Essential for ER stress-induced cell death.

Subunit:
Interacts with BCL2, BCL2L1/BCL-XL, MCL1 and BCL2A1.

Subcellular Location:
Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release.

Similarity:
Belongs to the Bcl-2 family.

Database links:

Entrez Gene: 27113 Human

Entrez Gene: 170770 Mouse

Entrez Gene: 317673 Rat

Omim: 605854 Human

SwissProt: Q9BXH1 Human

SwissProt: Q99ML1 Mouse

SwissProt: Q80ZG6 Rat

Unigene: 467020 Human

Unigene: 7660 Mouse

Unigene: 25176 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

PUMA在由p53誘導而經(jīng)歷細胞凋亡的細胞中被p53活化。在線粒體,PUMA 誘導細胞色素C的釋放和激活對細胞凋亡的快速誘導。PUMA 與Bcl2、Bcl-XL、類Bcl2-1蛋白相互作用,促使線粒體易位和BAX的多聚化。PUMA在通過依賴細胞色素C/APAF1 途徑介導p53誘導的細胞死亡中也發(fā)揮作用。
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