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Rabbit Anti-Lipoprotein lipase/PE Conjugated antibody (bs-1973R-PE)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1973R-PE
英文名稱 Rabbit Anti-Lipoprotein lipase/PE Conjugated antibody
中文名稱 PE標記的脂蛋白脂酶抗體
別    名 Lipoprotein lipase; LIPD; LIPL_HUMAN; LPL; LPL protein; EC 3.1.1; EC 3.1.1.34; HDLCQ11; LPL; LPL protein; MGC137861.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  免疫學  細胞粘附分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat,  (predicted: Pig, Cow, Rabbit, Sheep, Guinea Pig, )
產品應用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
細胞定位 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LPL
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 ℃ for one year. Protect from light.
產品介紹 background:
Lipoprotein lipase (LPL) is the central enzyme in plasma triglyceride hydrolysis and is secreted by macrophages in the subendothelial space. Evidence has been provided that LPL produced by macrophages in the vessel wall exerts proatherogenic effects. The atherogenic effects of LPL have been mainly attributed to its ability to favor lipid accumulation within macrophages present in the atherosclerotic lesion. Recently, it has also been shown that LPL promote the development of atherosclerosis through facilitation of monocyte adhesion to endothelial cells, stimulation of tumor necrosis factor alpha (TNF ) secretion and induction of vascular smooth muscle cell proliferation.

Function:
Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69.

Subunit:
Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids. Interacts with GPIHBP1.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles.

Tissue Specificity:
Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T lymphocytes, neutrophils, monocytes, B lymphocytes, and myeloid cells.

Post-translational modifications:
Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.

DISEASE:
Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]; also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.

Similarity:
Belongs to the AB hydrolase superfamily. Lipase family.
Contains 1 PLAT domain.

Database links:

Entrez Gene: 280843 Cow

Entrez Gene: 4023 Human

Entrez Gene: 16956 Mouse

Omim: 238600 Human

SwissProt: P11151 Cow

SwissProt: P06858 Human

SwissProt: P11152 Mouse

Unigene: 180878 Human

Unigene: 1514 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

脂蛋白脂酶(lipoprteinlipase,LPL)是甘油三酯降解為甘油和游離脂肪酸 (FFA)反應的限速酶,是脂肪細胞、心肌細胞、骨骼肌細胞、乳腺細胞以及巨噬細胞等實質細胞合成和分泌的一種糖蛋白與機體的脂質代謝及肥胖與否密切相關. 近年來研究認為:LPL可通過粘附作用,促進了單核細胞血管內皮細胞及腫瘤壞死因子(TNF)的分泌、血管平滑肌細胞增殖等因素,導致動脈粥樣硬化的加重。
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