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          Rabbit Anti-Kv4.2/PE Conjugated antibody (bs-9442R-PE)
          訂購熱線:400-901-9800
          訂購郵箱:sales@bioss.com.cn
          訂購QQ:  400-901-9800
          技術支持:techsupport@bioss.com.cn
          說 明 書: 100ul  
          100ul/2980.00元
          大包裝/詢價
          產品編號 bs-9442R-PE
          英文名稱 Rabbit Anti-Kv4.2/PE Conjugated antibody
          中文名稱 PE標記的電壓門控性鉀通道蛋白Kv4.2抗體
          別    名 Potassium voltage-gated channel subfamily D member 2; KCD2; KCND 2; KCND2; KCND2_HUMAN; KIAA1044; Potassium voltage gated channel Shal related subfamily member 2; RK 5; RK5; Voltage gated potassium channel Kv4.2; Voltage gated potassium channel subunit Kv4.2; Voltage sensitive potassium channel; voltage-gated potassium channel Kv4.2; Voltage-gated potassium channel subunit Kv4.2; voltage-sensitive potassium channel.  
          規格價格 100ul/2980元 購買        大包裝/詢價
          說 明 書 100ul  
          研究領域 心血管  神經生物學  通道蛋白  
          抗體來源 Rabbit
          克隆類型 Polyclonal
          交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
          產品應用 IF=1:50-200 
          not yet tested in other applications.
          optimal dilutions/concentrations should be determined by the end user.
          分 子 量 69kDa
          細胞定位 細胞膜 
          性    狀 Lyophilized or Liquid
          濃    度 1mg/ml
          免 疫 原 KLH conjugated synthetic peptide derived from human KCND2/Kv4.2
          亞    型 IgG
          純化方法 affinity purified by Protein A
          儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
          保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
          產品介紹 background:
          Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

          Function:
          Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

          Subunit:
          Homotetramer or heterotetramer with KCND1 and/or KCND3. Interacts with DPP6, DLG4 and NCS1/FREQ (By similarity). Interacts with DLG1. Associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 and KCNIP4. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. The KCND2-KCNIP2 channel complex contains four KCND2 and four KCNIP2 subunits. Interacts with FLNA, FLNC and DPP10.

          Subcellular Location:
          Cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Detected in dendrites in cultured hippocampal neurons. Association with KCNIP2 probably enhances cell surface expression.

          Tissue Specificity:
          Highly expressed throughout the brain. Expression is very low or absent in other tissues.

          Post-translational modifications:
          Phosphorylated on serine and threonine residues.

          Similarity:
          Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.

          Database links:

          Entrez Gene: 3751 Human

          Omim: 605410 Human

          SwissProt: Q9NZV8 Human

          Unigene: 654739 Human



          Important Note:
          This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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