超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
99久久国产免费,国产xxxx在线观看,中文免费av
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-NSE2/MMS21/AP Conjugated antibody (bs-9544R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-9544R-AP
英文名稱 Rabbit Anti-NSE2/MMS21/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的E3連接酶MMS21蛋白抗體
別    名 C8orf36; E3 SUMO-protein ligase NSE2; hMMS21; hNSE2; methyl methanesulfonate sensitivity gene 21; MMS21; MMS21 homolog; non-SMC element 2; Non-SMC element 2 homolog; Non-structural maintenance of chromosomes element 2 homolog; NSE2_HUMAN; NSMCE2.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  細胞凋亡  表觀遺傳學  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMS21/NSE2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Breaks in double stranded DNA often arise during DNA replication or as a result of exposure to DNA-damaging agents. Quick and accurate repair of these breaks is crucial for cell survival and genomic stability. Structural maintenance of chromosomes (SMC) family members form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation during mitosis. SMC5 and SMC6 play a crucial role in DNA repair as they form a complex with six conserved nonSMC subunits, including a ubiquitin E3 ligase NSE1 and a SUMO ligase NSE2. Specifically, this complex is crucial for sister chromatid homologous recombination DNA repair and also for prevention of chromosomal rearrangements. The NSE1 protein contains a RING-like motif that promotes DNA repair functions of the SMC5/SMC6 complex and full deletion of NSE1 is lethal to cells. NSE2 stimulates sumoylation of SMC6 and the DNA repair protein TRAX. Depletion of the NSE2 protein by RNA interference leaves the cell vulnerable to DNA damage-induced apoptosis.

Function:
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Subunit:
Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2.

Subcellular Location:
Nucleus.Chromosome, telomere. Note=Localizes to PML nuclear bodies in ALT cell lines.

Post-translational modifications:
Sumoylated, possibly via autosumoylation.

Similarity:
Belongs to the NSE2 family.
Contains 1 SP-RING-type zinc finger.

Database links:

Entrez Gene: 286053 Human

SwissProt: Q96MF7 Human

Unigene: 388297 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 国产精品国产三级国产普通话一 | 2020日日夜夜噜噜噜com | 免费看成年人视频在线 | 国产视频一二 | 99riav.6国产情侣在线看 | 欧美三级欧美成人高清www | 99精品免费观看 | 亚洲免费人成视频观看 | 欧美性另类69xxxx最新章节 | 欧亚洲嫩模精品一区三区 | 中文字幕成熟丰满人妻 | 天堂久久久久VA久久久久 | 精品综合久久久久 | 寂寞少妇被猛烈进入在线兔费观看 | 国产一级一级理论片一区二区 | 亚洲品质自拍视频 | 免费在线a级片 | 欧美91 | 日韩精品人妻中文字幕有码 | 91中文啦 | 男女啪啪免费观看无遮挡 | 91视频导航 | 98国产精品午夜免费福利视频 | 一级猛片免费看 | 亚洲国产欧美中文手机在线 | 亚洲伊人久久精品影院一美女洗澡 | 红桃影视成人免费 | 亚洲日韩中文字幕在线播放 | 亚洲AV无码乱码在线观看看 | 亚洲视频免费看 | 亚洲色素色无码专区 | 好男人资源在线观看好 | 欧美性猛交xxxx乱大交久久 | 五月天爱爱视频 | 无遮无码免费裸交视频 | 日韩中出 | 欧美第一在线视频 | 亚洲成人资源在线 | 国产成人精品久久亚洲高清不卡p | 高清中文字幕一区二区三区 | 亚洲伦理影院 |