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Rabbit Anti-COL6A5/PE-Cy5.5 Conjugated antibody (bs-11047R-PE-Cy5.5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11047R-PE-Cy5.5
英文名稱 Rabbit Anti-COL6A5/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的6型膠原蛋白α5抗體
別    名 Collagen VI alpha 5; CO6A5_HUMAN; COL29A1; Col6a5; Collagen alpha-1(XXIX) chain; Collagen alpha-5(VI) chain; Collagen, type VI, alpha 5; Collagen, type XXIX, alpha-1; Gm7455; von Willebrand factor A domain-containing protein 4; VWA4.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 發育生物學  神經生物學  信號轉導  細胞粘附分子  細胞外基質  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 288kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human COL6A5/Collagen VI alpha 5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a collagen that contains N- and C-terminal von Willebrand factor A-like domains. The encoded protein may interact with the alpha 1 and alpha 2 chains of collagen VI to form the complete collagen VI trimer. Sequence polymorphisms in this gene have been linked to atopic dermatitis (eczema). Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene.

Function:
Collagen VI acts as a cell-binding protein.

Subunit:
Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-5(VI) or alpha-6(VI)

Subcellular Location:
Secreted, extracellular space, extracellular matrix. Note=Deposed in the extracellular matrix of skeletal muscle.

Tissue Specificity:
Expressed in skin, followed by lung, small intestine, colon and testis. In skin, it is expressed in the epidermis with strongest staining in suprabasal viable layers. In ATOD patients, it is absent in the most differentiated upper spinous and granular layers (at protein level).

Post-translational modifications:
Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains

DISEASE:
Note=Patients affected by atopic dermatitis display an abnormal distribution of COL29A1 mRNA and protein in skin suggesting that COL29A1 may be involved in the pathogenesis of the disease.

Similarity:
Belongs to the type VI collagen family.
Contains 10 VWFA domains.

Database links:
Entrez Gene: 256076 Human

Omim: 611916 Human

SwissProt: A8TX70 Human

Unigene: 205403 Human

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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