超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
九一免费观看,91综合视频在线观看,亚洲人成A片在线观看
Rabbit Anti-KCNMA1/BK channel/BF555 Conjugated antibody (bs-4775R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-4775R-BF555
英文名稱 Rabbit Anti-KCNMA1/BK channel/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的鈣激活鉀通道蛋白α1抗體
別    名 subfamily M subunit alpha-1; BK channel; BKCA alpha; BKCA alpha subunit; BKTM; Calcium-activated potassium channel; Calcium-activated potassium channel subunit alpha-1; Drosophila slowpoke like; hSlo; K(VCA)alpha; KCa1.1; KCMA1_HUMAN; KCNMA; KCNMA1; Maxi K channel; Maxi Potassium channel alpha; MaxiK; SAKCA; SLO alpha; SLO; Slo homolog; Slo-alpha; Slo1; Slowpoke homolog.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  細胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  通道蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Chicken, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 137kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BKCA alpha
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

Function:
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).

Subunit:
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily. Contains 1 RCK N-terminal domain.

Subcellular Location:
Membrane.

Tissue Specificity:
Widely expressed. Except in myocytes, it is almost ubiquitously expressed.

Post-translational modifications:
Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity.

DISEASE:
Defects in KCNMA1 are the cause of generalized epilepsy and paroxysmal dyskinesia (GEPD) [MIM:609446]. Epilepsy is one of the most common and debilitating neurological disorders. Paroxysmal dyskinesias are neurological disorders characterized by sudden, unpredictable, disabling attacks of involuntary movement often requiring life-long treatment. The coexistence of epilepsy and paroxysmal dyskinesia in the same individual or family is an increasingly recognized phenomenon. Patients manifest absence seizures, generalized tonic-clonic seizures, paroxysmal nonkinesigenic dyskinesia, involuntary dystonic or choreiform movements. Onset is usually in childhood and patients may have seizures only, dyskinesia only, or both.

Similarity:
Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
Contains 1 RCK N-terminal domain.

Database links:

Entrez Gene: 374065 Chicken

Entrez Gene: 282573 Cow

Entrez Gene: 403984 Dog

Entrez Gene: 3778 Human

Entrez Gene: 16531 Mouse

Entrez Gene: 83731 Rat

Omim: 600150 Human

SwissProt: Q8AYS8 Chicken

SwissProt: Q28204 Cow

SwissProt: Q28265 Dog

SwissProt: Q12791 Human

SwissProt: Q08460 Mouse

SwissProt: Q9BG98 Rabbit

SwissProt: Q62976 Rat

Unigene: 144795 Human

Unigene: 343607 Mouse

Unigene: 486347 Mouse

Unigene: 30616 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 黄页免费看| 国产网红无码精品视频 | 国产又爽又黄又舒服又刺激视频 | 日本天天躁狠狠躁噜噜噜 | 欧美人妻一区二区三区 | 久久无码色综合中文字幕 | 欧美精品高清在线观看 | 大又大粗又爽又黄少妇毛片免费 | 91麻豆精品国产91久久久使用方法 | 免费无码高潮流白浆视频 | 天天操天天草 | 亚洲成年人网址 | 亚洲精品国产综合99久久夜夜嗨 | 黄色片免费网站 | 色与欲影视天天看综合网 | 国产亚洲色婷婷久久99精品 | 亚洲精品无码少妇30P | 97色mm五月天亚洲 | 91啦九色| 啦啦啦资源在线观看视频 | 最新国产一区 | 日本伊人精品一区二区三区介绍 | 欧美日韩在线资源 | 4438成人大色 | 逼逼综合网 | 国产丰满老熟女一区二区三区 | 高清中文字幕在线 | 少妇被大黑捧猛烈进出A片 久久亚洲视频网 | 国产精品原创av片国产日韩 | 2020日日夜夜噜噜噜com | 欧美一级特黄aaaaaa在线看片 | 1v1双性受整夜不拔bl | 免费看黄色的网站 | 成人91av| 国产一区二区精彩视频 | 亚洲国产精品无码久久一区二区 | 亚洲永久网站 | 4虎永久| 好男人好资源神马在线观看 | 中文字幕在线免费看 | 亚洲综合区夜久久无码精品 |