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Rabbit Anti-VEGFB/Gold Conjugated antibody (bs-10072R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-10072R-Gold
英文名稱 Rabbit Anti-VEGFB/Gold Conjugated antibody
中文名稱 膠體金標記的血管內皮生長因子B
別    名 Vascular endothelial growth factor B; VEGF B; VEGFB; VEGF-B; VEGF related factor; VEGFL; Vrf; vascular endothelial growth factor B isoform VEGFB-167 precursor; VEGFB_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  細胞生物  神經生物學  生長因子和激素  激酶和磷酸酶  細胞膜受體  血管內皮細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Guinea Pig, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 22kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human VEGFB
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described and include fibroblast growth factor (FGF), platelet derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs). The VEGF protein family is comprised of VEGF, VEGF-B, VEGF-C and VEGF-D, all of which may exhibit angiogenic function in vivo. VEGF-B, which exists as two alternatively spliced isoforms known as VEGF-B167 and VEGF-B186, is abundantly expressed in heart and skeletal muscle and is frequently co-expressed with VEGF. VEGF-C binds to and specifically activates Flt-4 and Flk-1.

Function:
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

Subcellular Location:
Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

Tissue Specificity:
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.

Post-translational modifications:
VEGF-B167 is O-glycosylated.

Similarity:
Belongs to the PDGF/VEGF growth factor family.

Database links:

Entrez Gene: 7423 Human

Entrez Gene: 22340 Mouse

Entrez Gene: 89811 Rat

Omim: 601398 Human

SwissProt: P49765 Human

SwissProt: P49766 Mouse

SwissProt: O35485 Rat

Unigene: 78781 Human

Unigene: 15607 Mouse

Unigene: 198550 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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