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Rabbit Anti-BHLHB9/p60TRP/AP Conjugated antibody (bs-11653R-AP)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-11653R-AP
英文名稱 Rabbit Anti-BHLHB9/p60TRP/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的p60TRP蛋白抗體
別    名 Basic helix loop helix domain containing class B 9; BHLHB 9; bHLHB9; KIAA1701; p60 like protein; p60TRP; Protein BHLHb9; Transcription regulator of 60 kDa; BHLH9_HUMAN .  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  神經生物學  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 60kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BHLHB9/p60TRP (451-547aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Basic helix-loop-helix (bHLH) proteins are a group of transcription factors that influence the regulation of neurogenesis, cardiogenesis, myogenesis, differentiation and cell proliferation. p60TRP (p60-transcription-regulator-protein), also known as BHLHb9 (basic helix-loop-helix domain containing, class B, 9) or p60-like protein, is a 547 amino acid cytoplasmic and nuclear protein that belongs to the GPRASP family. A few members of the GRASP family are considered G protein-coupled receptors that play a role in many different stimulus-response pathways. Highly expressed in brain, p60TRP may be involved in the control of cellular aging and survival. In colon cancer cells, p60TRP is down regulated due to CpG hypermethylation of its promoter, and patients suffering from Alzheimer disease have low levels of p60TRP. p60TRP binds to karyopherin ∫3, also known as Ran BP-5, and protein-phosphatase-2A (PP2A), and is encoded by a gene located on human chromosome Xq22.1.

Function:
BHLHB9, or basic helix loop helix domain containing, class B 9, interacts with the Ran-binding-protein-5 (RanBP5) and the protein-phosphatase-2A (PP2A). It can also affect NNT1 and p48ZnF signaling and is down-regulated in the brain of AD subjects. Thus BHLHB9 may have a possible pivotal role in the control of cellular aging and survival. Hypermethylation of the BHLHB9 gene occurs in premalignant lesions and accumulates during tumorigenesis.

Subcellular Location:
Cytoplasm. Nucleus. Note=Mainly cytoplasmic, and nuclear at lower level.

Tissue Specificity:
Highly expressed in brain. Not expressed in lung or liver. Down-regulated in brain from patients suffering from Alzheimer disease.

Similarity:
Belongs to the GPRASP family.

Database links:
UniProtKB/Swiss-Prot: Q6PI77.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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