| 產(chǎn)品編號(hào) | bs-11680R-Gold |
| 英文名稱(chēng) | Rabbit Anti-BACE2/Gold Conjugated antibody |
| 中文名稱(chēng) | 膠體金標(biāo)記的β淀粉樣前體蛋白裂解酶2抗體 |
| 別 名 | ALP 56; ALP-56; ALP56; ALP56; Asp 1; ASP1; ASP1; ASP21; Aspartic Like Protease 56kDa; Aspartic Like Protease 56kDa; Aspartic-like protease 56 kDa; Aspartyl protease 1; Aspartyl protease 1; BACE 2; BACE 2; Bace2; BACE2_HUMAN; Beta Secretase 2; Beta Secretase 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2; Beta-secretase 2; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; Down region aspartic protease; Downs Syndrome Region Aspartic Protease; Downs Syndrome Region Aspartic Protease; DRAP; Memapsin 1; Memapsin1; Memapsin-1; Membrane associated aspartic protease 1; Membrane-associated aspartic protease 1; Theta-secretase. |
| 規(guī)格價(jià)格 | 100ul/2980元 購(gòu)買(mǎi) 大包裝/詢價(jià) |
| 說(shuō) 明 書(shū) | 100ul（10nm 15nm 35nm） |
| 研究領(lǐng)域 | 細(xì)胞生物 神經(jīng)生物學(xué) Alzheimer's |
| 抗體來(lái)源 | Rabbit |
| 克隆類(lèi)型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Mouse, Rat, Dog, ) |
| 產(chǎn)品應(yīng)用 | IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 0.4mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human BACE2 (101-200aa) |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲(chǔ) 存 液 | 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. |
| 保存條件 | Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles. |
| 產(chǎn)品介紹 |
background: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Subunit: Monomer. Interacts ith RTN3 and RTN4. Subcellular Location: Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface. Tissue Specificity: Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate. Post-translational modifications: Undergoes autoproteolytic cleavage. Glycosylated. Similarity: Belongs to the peptidase A1 family. Database links: Entrez Gene: 25825 Human Entrez Gene: 56175 Mouse Omim: 605668 Human SwissProt: Q9Y5Z0 Human SwissProt: Q9JL18 Mouse Unigene: 529408 Human Unigene: 97885 Mouse Unigene: 38581 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
