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Rabbit Anti-CD137/APC Conjugated antibody (bs-2449R-APC)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2449R-APC
英文名稱 Rabbit Anti-CD137/APC Conjugated antibody
中文名稱 APC標記的腫瘤壞死因子受體超家族成員9抗體
別    名 Tumor necrosis factor receptor superfamily member 9; Tnfrsf9; TNFRSF9; 4-1BB; 4 1BB; 4 1BB ligand receptor; Homolog of mouse 4 1BB; Receptor protein 4 1BB; T cell antigen 4 1BB homolog; T cell antigen ILA; Cd137; CDw137; CD 137; CD137 antigen; Induced by lymphocyte activation; ILA; Interleukin activated receptor homolog of mouse Ly63; Ly63; MGC2172; MGC114552; OTTHUMP00000044294; TNR9_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  細胞凋亡  細胞膜受體  自然殺傷細胞  t-淋巴細胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD137
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
CD137 exists on the cell surface as a monomer with a molecular mass of 30 kDa and as a dimer of 55 kDa. Human and mouse CD137 share 60% amino acid identity. CD137 (4-1BB), a member of the tumour necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival.

Function:
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Subunit:
Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed on the surface of activated T-cells.

Similarity:
Contains 4 TNFR-Cys repeats.

Database links:

Entrez Gene: 3604 Human

Omim: 602250 Human

SwissProt: Q07011 Human

Unigene: 654459 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD137屬于腫瘤壞死因子超家族成員,是可誘導的T細胞共刺激受體,表達于CD4 + 和CD8 + T細胞、活化的自然殺傷細胞(natural killercell,NK)和樹突狀細胞,CD137可抑制T細胞增殖,誘發(fā)細胞凋亡。
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