超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
97色97,国产SUV精品一区二区,无码免费的毛片基地
Rabbit Anti-GRB10/Gold Conjugated antibody (bs-2769R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-2769R-Gold
英文名稱 Rabbit Anti-GRB10/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的生長因子受體結(jié)合蛋白10抗體
別    名 GRB IR; grb-10; GRB10 adaptor protein; GRBIR; Growth factor receptor bound protein 10; Insulin receptor binding protein; Insulin receptor binding protein GRB IR; IRBP; MEG1; RSS.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  生長因子和激素  激酶和磷酸酶  細(xì)胞膜受體  糖尿病  內(nèi)分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 65kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GRB10 (554-594aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

Function:
Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

Subunit:
Interacts with ligand-activated tyrosine kinase receptors, including FGFR1, INSR, IGF1R, MET and PDGFRB in a phosphotyrosine-dependent manner through the SH2 domain. Poorly binds to the EGFR. Directly interacts with MAP3K14/NIK and is recruited to the EGFR-ERBB2 complex. Interacts with GIGYF1/PERQ1 and GIGYF2/TNRC15. When unphosphorylated, interacts with AKT1 and when phosphorylated with YWHAE/14-3-3 epsilon. Interacts with NEDD4. Interacts with LRP6, thus interfering with the binding of AXIN1 to LRP6. Binds to activated NRAS.

Subcellular Location:
Cytoplasm. When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment.

Tissue Specificity:
Widely expressed in fetal and adult tissues, including fetal and postnatal liver, lung, kidney, skeletal muscle, heart, spleen, skin and brain.

Post-translational modifications:
phosphorylated on serine residues upon EGF, FGF and PDGF stimulation.

Similarity:
Belongs to the GRB7/10/14 family.
Contains 1 PH domain.
Contains 1 Ras-associating domain.
Contains 1 SH2 domain.

Database links:

Entrez Gene: 2887 Human

Entrez Gene: 14783 Mouse

Entrez Gene: 498416 Rat

Omim: 601523 Human

SwissProt: Q13322 Human

SwissProt: Q60760 Mouse

SwissProt: P0CE43 Rat

Unigene: 164060 Human

Unigene: 273117 Mouse

Unigene: 479549 Mouse

Unigene: 63942 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

生長因子受體結(jié)合蛋白10與胰島素抵抗、2型糖尿病以及個(gè)體生長發(fā)育有關(guān)。
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 国产69精品久久久久乱码韩国 | 亚洲一区区 | 中文字幕av免费在线观看 | 国产视频二区在线观看 | 国产自产精品一区 | 黄色wwwwwww | 日本无码一区二区三区在线观看 | 国产精品影院在线观看 | 天天av综合| 玄女心经国语免费观看 | 精品日本久久 | 免费一区在线观看 | 看曰本女人大战黑人视频 | 六十路の高齢熟女が | 91成品入口 | 亚色网址| 日韩精品人妻中文字幕有码 | 亚洲AV成人无码一区无广告 | 17C精品麻豆一区二区免费 | 国产专区91豆花 | 成人国产精品久久久久久亚洲 | 国产凸凹视频一区二区 | 99精品免费久久久久久日本 | 国产在线色 | 亚洲乱码国产乱码精品精的特点 | 欧美精品一区在线 | 色欲aⅴ亚洲情无码AV | 17C精品麻豆一区二区免费 | 亚洲一区二区三区在线网站 | 中文一国产一无码一日韩 | 国精产品深夜免费麦片 | 在线综合亚洲 | 手机看片被窝午夜婷婷国产 | 一本色道久久88亚洲精品综合 | 国产成人AV综合久久视色 | 亚洲欧美h | 婷婷综合久久一区二区三 | 精品人妻无码一区二区三区换脸 | 一区二区在线视频播放 | a天堂中文在线观看 | 成人性生生活性生交免费 |