超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
6精品国产乱码久久久久久,5060网午夜,www.久久r
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-Gab1 (Tyr627)/Cy3 Conjugated antibody (bs-3165R-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3165R-Cy3
英文名稱 Rabbit Anti-Phospho-Gab1 (Tyr627)/Cy3 Conjugated antibody
中文名稱 Cy3標記的磷酸化接頭蛋白Gab 1抗體
別    名 GAB1 (phospho Y627); Gab1(Phospho-Tyr627); p-Gab1 (Tyr627); GRB 2 associated binder 1; GRB 2 associated binding protein 1; GRB2 associated binding protein 1 isoform a; GRB2 associated binding protein 1 isoform bl; Gab 1; Gab1; GAB1_HUMAN; GRB2 associated binder 1; GRB2 associated binding protein 1 isoform b; GRB2-associated binder 1; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  心血管  細胞生物  信號轉導  細胞膜受體  糖尿病  內分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 76kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Gab1 around the phosphorylation site of Tyr627
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter proteins such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity (1-3,8). Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c Met), and epidermal growth factor receptor (EGF), as well as in response to cell cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3 kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF.

Function:
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).

Subunit:
Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2A, GRB2, GAB1, PIK3R1 and SOS1.

Post-translational modifications:
Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.

Similarity:
Belongs to the GAB family.
Contains 1 PH domain.

Database links:

Entrez Gene: 2549 Human

Entrez Gene: 14388 Mouse

Entrez Gene: 361388 Rat

Omim: 604439 Human

SwissProt: Q13480 Human

SwissProt: Q9QYY0 Mouse

Unigene: 618456 Human

Unigene: 80720 Human

Unigene: 277409 Mouse

Unigene: 1725 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Gab1作為一種分布廣泛的接頭蛋白,幾乎能連接所有類型的受體(如酪氨酸激酶受體、G-蛋白偶聯(lián)受體、細胞因子與抗原受體等,Gab1蛋白屬于接頭蛋白Gab家族,該家族蛋白因能與生長因子受體結合蛋白2(Grb2)相結合而得名。作為接頭蛋白,Gab1蛋白能被多種受體酪氨酸激酶或非受體酪氨酸激酶激活,接受胞外多種生長因子、細胞因子和一些T/B細胞抗原受體的刺激,介導PI3K/Akt和Ras/MAPK等多條信號轉導途徑,具有促進細胞生長、遷移、調節(jié)免疫等多種生物學功能,與糖尿病、腫瘤、心血管疾病等的發(fā)生發(fā)展密切相關。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: av片在线观看永久免费 | 国产丨综合丨精品入口 | 国产伦人人人人人人性 | 亚洲欧洲在线看 | 91中文啦 | 偷窥目拍性综合图区 | 亚洲精品视频在线播放 | 在线观看中文字幕一区二区 | 99久在线观看 | 九一免费网站 | 久久综合色视频 | 久久精品国产久精国产爱 | 亚洲一区二区精品在线观看 | 日本韩国国产 | 国产大学生一级毛片绿象 | 亚洲AV无码国产综合专区 | 国产va免费精品观看 | 亚洲熟啪啪偷拍 | 人人干夜夜 | 最近2018免费中文字幕4 | 亚洲av无码成h人动漫无遮 | 国产AV无码国产AV毛片 | 麻豆传传媒久久久爱 | 伦理片一区 | 国产特级毛片AAAAAA高潮流水 | 久久免费看少妇高潮a片特黄 | 一级毛片子 | 国产欧美精品一区二区三区小说 | 成人黄色视频免费观看 | 国产伦一区二区三区免费 | 国产情趣视频在线观看 | 国产大陆av | 色偷偷成人网免费视频男人的天堂 | 日韩视频精品在线 | 综合天天色 | 人人玩人人添人人澡超碰 | 亚洲AV无码国产精品色软件下戴 | 老司机久久一区二区三区 | 成人天堂噜噜噜 | 嫩草午夜| 久久精品国产一区二区无码 |