超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
6精品国产乱码久久久久久,5060网午夜,www.久久r
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-Gab1 (Tyr627)/Cy3 Conjugated antibody (bs-3165R-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3165R-Cy3
英文名稱 Rabbit Anti-Phospho-Gab1 (Tyr627)/Cy3 Conjugated antibody
中文名稱 Cy3標記的磷酸化接頭蛋白Gab 1抗體
別    名 GAB1 (phospho Y627); Gab1(Phospho-Tyr627); p-Gab1 (Tyr627); GRB 2 associated binder 1; GRB 2 associated binding protein 1; GRB2 associated binding protein 1 isoform a; GRB2 associated binding protein 1 isoform bl; Gab 1; Gab1; GAB1_HUMAN; GRB2 associated binder 1; GRB2 associated binding protein 1 isoform b; GRB2-associated binder 1; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  心血管  細胞生物  信號轉導  細胞膜受體  糖尿病  內分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 76kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Gab1 around the phosphorylation site of Tyr627
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter proteins such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity (1-3,8). Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c Met), and epidermal growth factor receptor (EGF), as well as in response to cell cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3 kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF.

Function:
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).

Subunit:
Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2A, GRB2, GAB1, PIK3R1 and SOS1.

Post-translational modifications:
Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.

Similarity:
Belongs to the GAB family.
Contains 1 PH domain.

Database links:

Entrez Gene: 2549 Human

Entrez Gene: 14388 Mouse

Entrez Gene: 361388 Rat

Omim: 604439 Human

SwissProt: Q13480 Human

SwissProt: Q9QYY0 Mouse

Unigene: 618456 Human

Unigene: 80720 Human

Unigene: 277409 Mouse

Unigene: 1725 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Gab1作為一種分布廣泛的接頭蛋白,幾乎能連接所有類型的受體(如酪氨酸激酶受體、G-蛋白偶聯(lián)受體、細胞因子與抗原受體等,Gab1蛋白屬于接頭蛋白Gab家族,該家族蛋白因能與生長因子受體結合蛋白2(Grb2)相結合而得名。作為接頭蛋白,Gab1蛋白能被多種受體酪氨酸激酶或非受體酪氨酸激酶激活,接受胞外多種生長因子、細胞因子和一些T/B細胞抗原受體的刺激,介導PI3K/Akt和Ras/MAPK等多條信號轉導途徑,具有促進細胞生長、遷移、調節(jié)免疫等多種生物學功能,與糖尿病、腫瘤、心血管疾病等的發(fā)生發(fā)展密切相關。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 3ce奇米四色眼影奇米8888 | 人人玩人人添人人澡免费 | 国产婷婷一区二区 | 日韩无砖专区一中文字目 | 成人网站免费观看 | 国产精品自在拍首页视频8 日本不卡1 | 黄色拍拍视频 | 一级免费播放 | 国产成人一二三 | 久久久久无码精品国产 | 久久人人爽人人爽人人片av超碰 | 色综合.com| 亚洲精品专区 | av网站亚洲| 欧美精品在线观看一区 | 一级高清 | 少妇人妻偷人精品无码视频新浪 | 天地资源在线观看高清 | 黄色一级大片 | 久久国产精99精产国高潮 | 男的操女的免费视频 | 日韩精品综合网 | 久久精品国产亚洲AV大全 | 国产亚洲av片在线观看18女人 | 久久精品成人免费国产 | 日本三级欧美三级人妇视频黑白配 | avtom影院永久入口满18 | 亚洲色欧美在线影院 | 久久久久久国产一级毛片... | 一夜新娘第三季在线观看 | 日韩wwww| 4455国产精品视频 | 在线免费黄| 少妇的bbw性大片 | 日本a网| 放个毛片看看 | 99国产精品99久久久久久 | 国产精品久久呻吟 | 扒丝袜网www午夜一区二区三区 | 欧美极品少妇性运交 | 欧美A级毛欧美1级A大片 |