超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
青青青草伊人,91天堂在线视频,国产精区一区二区
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-Smad1 (Ser206)/Biotin Conjugated antibody (bs-3417R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3417R-Bio
英文名稱 Rabbit Anti-Phospho-Smad1 (Ser206)/Biotin Conjugated antibody
中文名稱 生物素標記的磷酸化細胞信號轉導分子Smad-1抗體
別    名 Smad1 (phospho S206); Smad1 (phospho Ser206); p-Smad1 (Ser206); Mothers against decapentaplegic homolog 1; BSP 1; BSP1; BSP-1; Dwarfin A; DwfA; hSMAD 1; hSMAD1; JV 41; JV4 1; JV4-1; JV41; MAD mothers against decapentaplegic homolog 1; Mad related protein 1; MADH 1; MADH1; Madr 1; MADR1; Mothers against decapentaplegic homolog 1; Mothers against DPP homolog 1; Sma and Mad related protein 1; SMAD 1; SMAD-1; SMAD family member 1; SMAD mothers against DPP homolog 1 Drosophila; Spinal muscular atrophy distal with upper limb predominance; TGF beta signaling protein 1; Transforming growth factor beta signaling protein 1; SMAD1_HUMAN; MAD homolog 1; Mothers against DPP homolog 1; Mad-related protein 1; SMAD family member 1; Smad1; Transforming growth factor-beta-signaling protein 1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  免疫學  信號轉導  干細胞  細胞凋亡  生長因子和激素  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse,  (predicted: Rat, )
產品應用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Smad1 around the phosphorylation site of Ser206
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].

Function:
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

Subunit:
Interacts with HGS, NANOG and ZCCHC12. May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with SKOR1. Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome.

Subcellular Location:
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane.

Tissue Specificity:
Ubiquitous. Highest expression seen in the heart and skeletal muscle.

Post-translational modifications:
Phosphorylated on serine by BMP type 1 receptor kinase.
Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.

DISEASE:
Defects in SMAD1 may be a cause of primary pulmonary hypertension (PPH1) [MIM:178600]. A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial PPH1 is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs.

Similarity:
Belongs to the dwarfin/SMAD family.
Contains 1 MH1 (MAD homology 1) domain.
Contains 1 MH2 (MAD homology 2) domain.

Database links:

Entrez Gene: 4086 Human

Entrez Gene: 17125 Mouse

Entrez Gene: 25671 Rat

Omim: 601595 Human

SwissProt: Q15797 Human

SwissProt: P70340 Mouse

SwissProt: P97588 Rat

Unigene: 604588 Human

Unigene: 223717 Mouse

Unigene: 10635 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Smads最新發現的TGF-β信號轉導途徑中一個重要的新基因家族.是TGF-β特異的細胞內信號轉導分子,SMAD1屬于受體激活的SMADs.有學者認為:Smad1在某些腫瘤中發生突變,有可能是一種腫瘤抑制基因。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 正在播放白领少妇第一次 | 欧美精品激情 | 中国一级毛片 | 久久国产精品99久久久久 | 国产午夜成人久久无码一区二区 | 日本欧美在线视频 | 四虎海外网址 | 一本色道久久综合精品竹菊 | 免费a视频在线 | 亚洲精品久久AV无码蜜桃第1集 | 亚洲精品成人AA片在线播 | 丰满少妇三级全黄 | 亚洲日本高清成人AⅤ片 | 国产精品区一区二区三在线播放 | 99久久精品无免国产免费75 | 欧美日韩国产成人高清视频 | 草逼网首页 | 闷骚的老熟女人15P 夜夜操人人 | 18禁止观看强奷免费国产大片 | 国产成人综合亚洲专区 | 伊人成人在线 | 91免费看毛片| 精品亚洲永久免费 | 色网站综合| 操操操日日日干干干 | 国产成人亚洲精品无码Av大片 | 久久不见久久见www日本 | 亚洲.www| 久久91导航 | 国产超精品无码不卡AV | 中文字幕在线免费视频 | 99久久精品费精品国产风间由美 | 亚洲第一av片精品堂在线观看 | 狠狠操福利视频 | 国产ww久久久久久久久久 | 国产精品亚洲片在线观看不卡 | 7194中文乱码一二三四芒果 | 最新精品视频2020在线视频 | 狠狠爱无码一区二区三区 | 51社区在线成人免费视频 | 永久视频在线观看 |