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Rabbit Anti-Phospho-MARCKS (Ser152 + Ser156)/AP Conjugated antibody (bs-3263R-AP)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3263R-AP
英文名稱 Rabbit Anti-Phospho-MARCKS (Ser152 + Ser156)/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的磷酸化丙氨酸蛋白激酶C底物Marcks抗體
別    名 MARCKS (phospho S152 + S156); p-MARCKS (phospho S152 + S156); MARCKS (phospho S159 + S163); 80 kDa protein; 80K L; 80K L protein; 80K-L protein; 80KL; 81 kDa protein, light chain; light chain; MACS; MARCKS; MARCS; MARCS_RAT; MGC52672; myristoylated alanine rich C kinase substrate; Myristoylated alanine rich protein kinase C substrate (MARCKS, 80K L); Myristoylated alanine rich protein kinase C substrate; Myristoylated alanine-rich C-kinase substrate; Phosphomyristin; PKCSL; PRKCSL; protein kinase C substrate 80 kDa protein light chain; Protein kinase C substrate.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 心血管  免疫學  信號轉導  激酶和磷酸酶  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Chicken, Dog, Cow, Rabbit, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 30kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from rat MARCKS around the phosphorylation site of Ser152/156 or Ser159/163(human)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]

Function:
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.

Subcellular Location:
Cytoplasm, cytoskeleton (Probable). Membrane; Lipid-anchor.

Tissue Specificity:
Highest levels found in spleen and brain. Intermediate levels seen in thymus, ovary, lung and heart. Very low levels seen in kidney, skeletal muscle and liver.

Post-translational modifications:
Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.

Similarity:
Belongs to the MARCKS family.

Database links:

Entrez Gene: 4082 Human

Entrez Gene: 17118 Mouse

Entrez Gene: 25603 Rat

Omim: 177061 Human

SwissProt: P29966 Human

SwissProt: P26645 Mouse

SwissProt: P30009 Rat

Unigene: 519909 Human

Unigene: 712721 Human

Unigene: 30059 Mouse

Unigene: 9560 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MARCKS是一種分子量為32kDa的膜內蛋白,在組織中廣泛表達,但主要高表達在腦內的軸突、小直徑的樹突和樹突棘.
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