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Rabbit Anti-Myogenin/BF350 Conjugated antibody (bs-3550R-BF350)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3550R-BF350
英文名稱 Rabbit Anti-Myogenin/BF350 Conjugated antibody
中文名稱 BF350標記的肌細胞生成素抗體
別    名 MYOG; bHLHc3; cb553; MYF 4; MYF4; Myf-4; MYOG; Myogenic factor 4; Myogenic factor 4 myogenin; MYOGENIN; Myogenin myogenin factor 4; OTTHUMP00000039094; Class C basic helix-loop-helix protein 3; MYOG_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  激酶和磷酸酶  結合蛋白  細胞表面分子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Chicken,  (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 25kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MYOG/Myogenin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]

Function:
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts.

Subunit:
Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts (via C-terminus region) with SSRP1 and SUPT16H; the interaction is indicative of an interaction with the FACT complex.

Subcellular Location:
Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos.

Post-translational modifications:
Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles.

Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.

Database links:

Entrez Gene: 4656 Human

Entrez Gene: 17928 Mouse

Entrez Gene: 497618 Pig

Entrez Gene: 29148 Rat

Omim: 159980 Human

SwissProt: P15173 Human

SwissProt: P12979 Mouse

SwissProt: P49812 Pig

SwissProt: P20428 Rat

Unigene: 2830 Human

Unigene: 16528 Mouse

Unigene: 9465 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

MYOG是肌肉中運載氧的蛋白質,由153個氨基酸殘基組成,一種小分子蛋白質,含有血紅素,和血紅蛋白同源,與氧的結合能力介于血紅蛋白和細胞色素氧化酶之間,可幫助肌細胞將氧轉運到線粒體。 肌細胞生成素在成肌分化過程中起著決定性的作用。在人體骨骼肌的胚胎發育過程中 ,肌細胞生成素伴隨成肌過程而呈高水平表達。MYOG主要由腎臟代謝并排泄,當心肌或橫紋肌有損傷時,肌紅蛋白便釋放入血中,血清中的肌紅蛋白即可明顯升高。
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