超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
精品日韩三级,少妇裸体淫交视频免费看看,丁香五月亚洲春色
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Cytokeratin 1/Gold Conjugated antibody (bs-1244R-Gold)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-1244R-Gold
英文名稱 Rabbit Anti-Cytokeratin 1/Gold Conjugated antibody
中文名稱 膠體金標記的細胞角蛋白1抗體
別    名 Cytokeratin 1; 67 kDa cytokeratin; CK 1; CK1; Cytokeratin1; EHK1; Hair alpha protein; K 1; K1; Keratin 1; Keratin type II cytoskeletal 1; Keratin1; KRT 1; KRT1A; K2C1_HUMAN; Keratin, type II cytoskeletal 1; Cytokeratin-1; CK-1; Keratin-1; Type-II keratin Kb1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 腫瘤  信號轉導  干細胞  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rabbit,  (predicted: Rat, Dog, Cow, Horse, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cytokeratin 1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq].

Function:
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK.

Subunit:
Heterotetramer of two type I and two type II keratins. Keratin-1 is generally associated with keratin-10. Interacts with ITGB1 in the presence of GNB2L1 and SRC, and with GNB2L1. Interacts with C1QBP; the association represents a cell surface kininogen receptor.

Subcellular Location:
Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells.

Tissue Specificity:
The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.

Post-translational modifications:
Undergoes deimination of some arginine residues (citrullination).

DISEASE:
Defects in KRT1 are a cause of epidermolytic hyperkeratosis (EHK) [MIM:113800]. An autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
Defects in KRT1 are the cause of ichthyosis hystrix Curth-Macklin type (IHCM) [MIM:146590]. IHCM is a genodermatosis with severe verrucous hyperkeratosis. Affected individuals manifest congenital verrucous black scale on the scalp, neck, and limbs with truncal erythema, palmoplantar keratoderma and keratoses on the lips, ears, nipples and buttocks.
Defects in KRT1 are a cause of palmoplantar keratoderma non-epidermolytic (NEPPK) [MIM:600962]. NEPKK is a dermatological disorder characterized by focal palmoplantar keratoderma with oral, genital, and follicular lesions.
Defects in KRT1 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
Defects in KRT1 are the cause of palmoplantar keratoderma striate type 3 (SPPK3) [MIM:607654]; also known as keratosis palmoplantaris striata III. SPPK3 is a dermatological disorder affecting palm and sole skin where stratum corneum and epidermal layers are thickened. There is no involvement of non-palmoplantar skin, and both hair and nails are normal.

Similarity:
Belongs to the intermediate filament family.

Database links:

Entrez Gene: 3848 Human

Entrez Gene: 16678 Mouse

Entrez Gene: 300250 Rat

Omim: 139350 Human

SwissProt: P04264 Human

SwissProt: P04104 Mouse

SwissProt: Q6IMF3 Rat

Unigene: 80828 Human

Unigene: 183137 Mouse

Unigene: 31789 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

結構蛋白(Structural Proteins)
細胞角蛋白常用于腫瘤細胞的分化、增殖及轉移方面的研究。有學者認為:在腫瘤細胞分化過程中有細胞角蛋白的表達,把細胞角蛋白作為腫瘤干細胞的標志物。陽性部位:主要在胞漿。CK119, CK8, CK19同源.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 精品无人区无码乱码大片国产 | 人人99 | 精品久久久久中文字幕一区奶水 | 亚洲欧美国产日韩综合 | 日韩精品高清自在线等信息 | 看国产黄大片在线观看 | 国产成人自拍网 | 国产精品粉嫩av | 免费精品一区二区三区第35 | 黄色av地址 | 健身房啪啪的av片 | 在线视频亚洲欧美 | 国产精品私密保健会所 | 国产精品都在这里 | 中文高清无码人妻 | mm1313亚洲国产精品美女 | 久久久精品蜜桃 | 67194成人手机在线 | 一级特黄在线 | 国产麻豆乱子伦午夜视频观看 | 99精品国产一区 | 无码中文字幕AV带剧情 | 性少妇xxxxx 精品视频一二三 | 黄色wwwwwww | 深夜A级毛片视频免费 | 我要看黄色a级片 | 久草首页在线 | 综合图区亚洲欧美另类图片 | 免费看成年人视频在线 | 插插插操操操 | 午夜视频在线观看免费视频 | a级毛毛片| www.俺高潮了.com | 成人免费看片网 | 国产精品久久久久久久久侵犯 | 久久亚洲综合精品99国产 | 免费无码专区毛片高潮喷水 | 国语久久 | 成人做爽爽爽爽免费国产软件 | 四虎影视在线视频大全免费观看 | 日韩人妻无码系列专区 |