超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
天天天天天操,蜜乳av网站,在线成人精品视频
Rabbit Anti-Dengue virus envelope glycoprotein E/FITC Conjugated antibody (bs-0171R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-0171R-FITC
英文名稱 Rabbit Anti-Dengue virus envelope glycoprotein E/FITC Conjugated antibody
中文名稱 FITC標(biāo)記的登革熱病毒包膜糖蛋白E抗體
別    名 Dengue virus; DV1_gp1; Genome polyprotein; envelope glycoprotein (Dengue virus type-2); Dengue virus envelope glycoprotein E; Polyprotein; DEN polyprotein.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)菌及病毒  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng)
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Dengue virus type-2 envelope glycoprotein E
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.

Function:
prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity).
Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).
Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity).
Non-structural protein 2A may be involved viral RNA replication and capsid assembly (Potential).
Non-structural protein 2B is a required cofactor for the serine protease function of NS3 (By similarity).
Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity).
Non-structural protein 4A induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the NS3 helicase (By similarity).
Peptide 2k functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter (By similarity).
Non-structural protein 4B inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway (By similarity).
RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway.

Subcellular Location:
Capsid protein C: Virion (Potential).
Peptide pr: Secreted.
Small envelope protein M: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein.
Envelope protein E: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein.
Non-structural protein 1: Secreted. Host endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential).
Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential).
Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.
Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Remains non-covalently associated to NS3 protease (By similarity).
Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Located in RE-associated vesicles hosting the replication complex.
Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity).
RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Host nucleus. Note=Located in RE-associated vesicles hosting the replication complex.

Post-translational modifications:
Specific enzymatic cleavages in vivo yield mature proteins. The nascent protein C contains a C-terminal hydrophobic domain that act as a signal sequence for translocation of prM into the lumen of the ER. Mature protein C is cleaved at a site upstream of this hydrophobic domain by NS3. prM is cleaved in post-Golgi vesicles by a host furin, releasing the mature small envelope protein M, and peptide pr. Non-structural protein 2A-alpha, a C-terminally truncated form of non-structural protein 2A, results from partial cleavage by NS3. Peptide 2K acts as a signal sequence and is removed from the N-terminus of NS4B by the host signal peptidase in the ER lumen. Signal cleavage at the 2K-4B site requires a prior NS3 protease-mediated cleavage at the 4A-2K site.
RNA-directed RNA polymerase NS5 is phosphorylated on serines residues. This phosphorylation may trigger NS5 nuclear localization.
Envelope protein E and non-structural protein 1 are N-glycosylated.

Similarity:
In the N-terminal section; belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0-1 NS5-type methyltransferase family.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase C-terminal domain.
Contains 1 mRNA cap 0-1 NS5-type MT domain.
Contains 1 peptidase S7 domain.
Contains 1 RdRp catalytic domain.

Database links:
 Entrez Gene: 1494449 Dengue virus 2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

登革病毒(Dengue Virus,DEN)屬黃病毒科(flavlviridae)又稱漢坦病毒、黃病毒,是重要的蟲媒病毒之一,是引起流行性出血熱的主要原因。
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 超碰中文在线 | 伊人涩涩涩涩久久久AV | 宅男噜噜噜66在线观看 | 亚洲第一av网 | 天天爽夜夜爽人人爽 | 狠狠综合久久久久尤物丿 | 国产足浴漂亮丰满技师av | 伊人开心22.yiren亚洲 | 日韩推理片在线免费看网站 | 东京热人妻中文无码AV | 特色特黄a毛片高清免费观看 | 高清无码中字在线一区二区 | 国产高清一区二区三区四区 | 国产一级v片不卡在线 | 屁股大丰满高潮尖叫视频 | AV在线观看 | 亚洲精品午夜 | 亚洲精品人成网在线播放影院 | 日本中文字幕成人 | 成人国产精品齐天大性 | 国精品久久久久久久久久久58 | 宝贝张开腿嗯啊高潮了视频 | 男男gaygays熟睡入侵视频 | 波多野结衣AV一区二区无码 | 欧美性色黄大片 | 双腿张开被9个男人调教 | 人成久久 | 特级毛片A级毛片免费播放 婷婷久久久亚洲欧洲日产国码AV | www.日日干 | 久热中文字幕在线精品观 | 精品二区| 精品人妻无码一区二区三区竹菊影视 | 亚洲伊人色欲综合网 | 国产美女一级做受老师 | 一级国产片 | 中文字幕在线播放一区 | 亚洲精品久久无码AV片银杏 | 在线日一区 | 久久久久精彩视频 | 精品久久久久久久久久国产 | 91嫩草国产在线观看 |