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Rabbit Anti-CTDSPL/Gold Conjugated antibody (bs-3509R-Gold)
訂購熱線:400-901-9800
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產品編號 bs-3509R-Gold
英文名稱 Rabbit Anti-CTDSPL/Gold Conjugated antibody
中文名稱 膠體金標記的聯會復合體蛋白3抗體
別    名 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; CTD small phosphatase-like protein; CTDSL_HUMAN; CTDSP-like; Ctdspl; hYA22; NIF-like protein; NLI-interacting factor 1; Nuclear LIM interactor-interacting factor 1; Protein YA22; RBSP3; SCP3; Small C-terminal domain phosphatase 3; Small CTD phosphatase 3.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  免疫學  發育生物學  細胞周期蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, )
產品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SCP3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產品介紹 background:
During meiosis, the homologous chromosomes pair and recombine, a process essential for generating genetically distinct haploid cells. The unique behavior displayed by meiotic chromosomes has been linked to the activities of a meiosis-specific supramolecular proteinaceous structure, the synaptonemal complex (SC). Three meiosis-specific components of the SC have been characterized in mammals, SCP1, SCP2 and SCP3. SCP3 has a C-terminal coiled-coil domain that has been shown to promote homotypic interactions in vitro.

Function:
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.

Subunit:
Monomer. Interacts with REST.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expression is restricted to non-neuronal tissues.

Similarity:
Contains 1 FCP1 homology domain.

Database links:

Entrez Gene: 10217 Human

Entrez Gene: 69274 Mouse

Omim: 608592 Human

SwissProt: O15194 Human

SwissProt: P58465 Mouse

Unigene: 475963 Human

Unigene: 439928 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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