超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
zzzwww免费视频,欧美日韩亚洲一区二区三区四区 ,亚洲一区中文在线
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-cdc25C (Thr48)/PE-Cy5 Conjugated antibody (bs-3482R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3482R-PE-Cy5
英文名稱 Rabbit Anti-Phospho-cdc25C (Thr48)/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的磷酸化細胞分裂周期蛋白25C抗體
別    名 cdc25C(Phospho-Thr48); cdc25C(Phospho Thr48); cdc25C(Phospho T48); CDC 25; Cdc 25C; CDC25; CDC25C; Cell division cycle 25 homolog C; Cell Division Cycle 25C; Cell Division Cycle 25C; Cell division cycle 25C protein; Dual specificity phosphatase Cdc25C; M phase inducer phosphatase 3; M-phase inducer phosphatase 3; Mitosis inducer CDC25; MPIP3; MPIP3_HUMAN; Phosphotyrosine phosphatase.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  細胞生物  免疫學  信號轉導  細胞周期蛋白  轉錄調節因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human cdc25C around the phosphorylation site of Thr48
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]

Function:
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.

Subunit:
Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity. Interacts with MAPK14 and 14-3-3 proteins.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.

Similarity:
Belongs to the MPI phosphatase family.
Contains 1 rhodanese domain.

Database links:

Entrez Gene: 995 Human

Omim: 157680 Human

SwissProt: P30307 Human

Unigene: 656 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CDC25家族的組成哺乳動物中CDC25家族一共包括3種同源異構體(CDC25A、CDC25B、CDC25C),約有50%的序列同源,是一組在細胞周期調控中發揮巨大作用的蘇/酪氨酸雙功能酶 。不同的CDC25家族蛋白在細胞周期中的作用時相亦有差異,CDC25A和CDC25C分別在S期和M期發揮主要作用。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 人与禽一级一级毛片 | 好男人资源在线观看好 | 日韩精品dvd | 国产精品成人久久久久久久 | 国产av毛片一区二区三区 | 亚洲日韩制服丝袜中文字幕 | 人人澡人人干 | 亚洲AV成人综合网久久 | 精品偷拍自拍 | 久久久久久久久久久国产 | 特级毛片在线 | 国产精品推荐制服丝袜 | 特色特黄a毛片高清免费观看 | 国产精品一区二区久久精品爱涩 | 欧洲裸毛BBBBBXXXX | 亚洲欧美成人A∨在线观看 蝌蚪成人网 | 2021天天操| 无码A级毛片免费视频内谢 日韩欧美一区二区三区在线 | 佐山爱痴汉视频一区二区三区 | 伊人成人高清在线 | 亚洲伊人色欲综合网 | 国产人妻精品久久久久野外 | 日韩一卡2卡3卡4卡新区乱码在线观看 | 日韩精品一区二区三区在线 | 天天拍夜夜 | 黄色免费网站在线观看 | 山东中年夫妇大白天露脸自拍 | 精品久久久一二三区 | 欧美人牲口杂交在线播放免费 | 成人黄色a | 山东中年夫妇大白天露脸自拍 | 日本xxxxxxxxx70hd 国内外成人在线视频 | 国产精品无码日韩字幕资不卡 | 天天综合网久久 | 美国超碰在线 | 亚洲AV女人的天堂在线观看 | 欧美国产日本高清不卡 | 男子操女子视频 | 欧美亚洲另类激情另类 | 色呦呦欧美 | 青草青草久热精品 |