超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
大地影视资源在线观看,嫩草研究院在线观看,亚洲tv在线
Rabbit Anti-Phospho-cdc25C (Thr48)/BF594 Conjugated antibody (bs-3482R-BF594)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3482R-BF594
英文名稱 Rabbit Anti-Phospho-cdc25C (Thr48)/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的磷酸化細胞分裂周期蛋白25C抗體
別    名 cdc25C(Phospho-Thr48); cdc25C(Phospho Thr48); cdc25C(Phospho T48); CDC 25; Cdc 25C; CDC25; CDC25C; Cell division cycle 25 homolog C; Cell Division Cycle 25C; Cell Division Cycle 25C; Cell division cycle 25C protein; Dual specificity phosphatase Cdc25C; M phase inducer phosphatase 3; M-phase inducer phosphatase 3; Mitosis inducer CDC25; MPIP3; MPIP3_HUMAN; Phosphotyrosine phosphatase.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  細胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細胞周期蛋白  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human cdc25C around the phosphorylation site of Thr48
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]

Function:
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity.

Subunit:
Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity. Interacts with MAPK14 and 14-3-3 proteins.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by CHEK1 and MAPK14 at Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase. Phosphorylated by PLK4. Phosphorylated by PLK1, leading to activate the phosphatase activity. Phosphorylation by PLK3 at Ser-191 promotes nuclear translocation. Ser-198 is a minor phosphorylation site. Was initially reported to be phosphorylated by PLK3 at Ser-216 (PubMed:10557092). However, such phosphorylation by PLK3 was not confirmed by other groups. Phosphorylation at Thr-48, Thr-67, Ser-122, Thr-130, Ser-168 and Ser-214 occurs at G2 and G2-M transition and is probably catalyzed by CDK1. Ser-168 phosphorylation levels are lower than those at the other 5 CDK1 sites. Phosphorylation by CDK1 leads to increased activity.

Similarity:
Belongs to the MPI phosphatase family.
Contains 1 rhodanese domain.

Database links:

Entrez Gene: 995 Human

Omim: 157680 Human

SwissProt: P30307 Human

Unigene: 656 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CDC25家族的組成哺乳動物中CDC25家族一共包括3種同源異構(gòu)體(CDC25A、CDC25B、CDC25C),約有50%的序列同源,是一組在細胞周期調(diào)控中發(fā)揮巨大作用的蘇/酪氨酸雙功能酶 。不同的CDC25家族蛋白在細胞周期中的作用時相亦有差異,CDC25A和CDC25C分別在S期和M期發(fā)揮主要作用。
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 中文字幕在线播放一区 | 亚洲成人手机在线观看 | 日韩精品免费视频一区二区三区 | 99热这里精品 | 久草在线视频免赞 | 日韩在线免费视频观看 | 日韩在线观看一区 | 成人免费在线视频网站 | 欧美在线观看网站 | 四虎在线精品 | 亚洲成人日韩 | 韩日中文字幕第一页 | AV永久天堂一区二区三区香港 | ckplayer国产亚洲欧美 | 亚洲国产精品久久久久久 | 亚洲AV无码成人网站在线观看 | 久久99日韩| 亚洲国产国语自产精品 | 成人性色生活片 | 三区免费视频 | 91在线高清| 国产JJZZJJZZ视频全部免费 | 精品一区二区三区四区视频 | 亚色中文成人yase999co | 国产精品露脸国语对白 | 亚洲欧美成人A∨在线观看 蝌蚪成人网 | 国产福利一区二区三区在线播放 | 欧美激情在线免费观看 | 黄色网页你懂的 | 欧产日产国产精品乱噜噜 | 亚洲人成一区 | 无限在线观看片免费视频 | 131美女爽爽爽爱做视频 | 国产视频一区二区三区四区 | 成年女人免费又黄又爽视频 | 性中国videossexo另类 | 日本公妇乱淫免费视频一区三区 | av毛片在线观看地址 | 欧美精品一区二区三区久久久竹菊 | 模特三点尽露私拍在线 | 国产综合视频一区二区三区 |