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Rabbit Anti-PLASTIN3/AP Conjugated antibody (bs-3643R-AP)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3643R-AP
英文名稱 Rabbit Anti-PLASTIN3/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標(biāo)記的絲束蛋白T Plastin抗體
別    名 Plastin 3 (T isoform); PLS3; PLS 3; PLS-3; Plastin 3; Plastin3; Plastin-3; T fimbrin.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)胞分化  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 69kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PLASTIN3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
T Plastin is a representative of an important family of actin-cross-linking and -bundling proteins that organize most of the actin networks in cells. T Plastin is associated with the actin core bundle of microvilli, stereocilia and microspikes in epithelial cells and was proposed to participate in the assembly of these structures. In mesenchymal cells, T plastin localizes to focal adhesions and the leading edge, a broad lamellar membrane extension harboring a dynamic branched actin network. Recent studies have shown that T plastin has the potential to be a Sezary cell-specific marker valuable for diagnostic and treatment of Sezary syndrome.

Function:
Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia.

Subunit:
Monomer.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in a variety of organs, including muscle, brain, uterus and esophagus.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR

Similarity:
Contains 2 actin-binding domains.
Contains 4 CH (calponin-homology) domains.
Contains 2 EF-hand domains.

Database links:

Entrez Gene: 5358 Human

Entrez Gene: 102866 Mouse

Entrez Gene: 81748 Rat

Omim: 300131 Human

SwissProt: P13797 Human

SwissProt: Q99K51 Mouse

SwissProt: Q63598 Rat

Unigene: 496622 Human

Unigene: 28777 Mouse

Unigene: 32103 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

絲束(纖毛素)是肌動(dòng)蛋白結(jié)合蛋白家族的成員,存在于細(xì)胞支架的重組中. 絲束3是來(lái)源于纖毛素蛋白家族的T淋巴細(xì)胞特異肌動(dòng)蛋白成束蛋白。近年來(lái)T Plastin在用于sezary cell綜合征的研究方面較多。
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