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Rabbit Anti-Adiponectin receptor 2/Cy5 Conjugated antibody (bs-0611R-Cy5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0611R-Cy5
英文名稱 Rabbit Anti-Adiponectin receptor 2/Cy5 Conjugated antibody
中文名稱 Cy5標記的脂聯(lián)素受體2抗體
別    名 Adipo R2; Progestin and adipoQ receptor family member II; Adipor2; PAQR2; ADR2_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  免疫學  生長因子和激素  細胞膜受體  糖尿病  內分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat,  (predicted: Dog, Pig, )
產品應用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Adiponectin receptor 2 (315-340aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]

Function:
Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.

Subunit:
May form homo and heteromultimers.

Subcellular Location:
Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles.

Tissue Specificity:
Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung.

Similarity:
Belongs to the ADIPOR family.

Database links:

Entrez Gene: 79602 Human

Entrez Gene: 68465 Mouse

Entrez Gene: 404694 Pig

Entrez Gene: 312670 Rat

Omim: 607946 Human

SwissProt: Q86V24 Human

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

脂聯(lián)素與受體結合后具有增強胰島素敏感性,抗高血糖,抗動脈粥樣硬化等生物學效應,任何增加或減少脂聯(lián)素及其受體表達的方法都影響這些疾病的發(fā)生和發(fā)展。
脂聯(lián)素受體(AdipoR1和AdipoR2)同屬于PAQR家族,具有七次跨膜蛋白的特有結構.
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