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Rabbit Anti-Leptin/BF647 Conjugated antibody (bs-0108R-BF647)
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0108R-BF647
英文名稱 Rabbit Anti-Leptin/BF647 Conjugated antibody
中文名稱 BF647標記的瘦素抗體
別    名 LEP; Leptin Murine Obesity Homolog; Leptin Precursor Obesity Factor; OB; Obese Protein; Obesity; Obesity factor; Obesity homolog mouse; Obesity Murine Homolog Leptin; OBS; LEP_MOUSE.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  神經生物學  信號轉導  干細胞  生長因子和激素  糖尿病  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 16kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Leptin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008].

Function:
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.

Subunit:
Interacts with SIGLEC6.

Subcellular Location:
Secreted (Probable).

DISEASE:
Leptin deficiency (LEPD) [MIM:614962]: A rare disease characterized by low levels of serum leptin, severe hyperphagia and intractable obesity from an early age. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the leptin family.

Database links:

Entrez Gene: 3952 Human

Entrez Gene: 16846 Mouse

Entrez Gene: 25608 Rat

Omim: 164160 Human

SwissProt: P41159 Human

SwissProt: P41160 Mouse

SwissProt: Q29406 Pig

SwissProt: P50596 Rat

SwissProt: Q28603 Sheep

Unigene: 194236 Human

Unigene: 277072 Mouse

Unigene: 44444 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Leptin是一種分子量為16kDa的脂肪組織源激素,又稱:肥胖蛋白(Obese-protein)是由脂肪細胞分泌的,具有強親水性,以單體形式存在于血漿中。
Leptin 具有廣泛的生物學效應,作用于下丘腦,調節食欲、能量代謝及體重。Leptin 還可能作為脂肪-胰島內分泌軸的一部分,參與胰島素分泌的調節。
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