超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
中国裸体BBBBXXXX,亚洲毛片一区二区,国产区91
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-GRK5/PE-Cy3 Conjugated antibody (bs-7540R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7540R-PE-Cy3
英文名稱 Rabbit Anti-GRK5/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的G蛋白偶聯受體激酶5抗體
別    名 G protein coupled receptor kinase 5; G protein coupled receptor kinase GRK5; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5; GPRK5; GRK5; GRK5_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  信號轉導  轉錄調節因子  激酶和磷酸酶  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GRK5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008].

Function:
Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).

Subunit:
Interacts with ST13 (via the C-terminus 303-319 AA). Interacts with TP53/p53. Interacts with HTR4 (via C-terminus 330-346 AA); this interaction is promoted by 5-HT (serotonin). Interacts with HDAC5.

Subcellular Location:
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion.

Tissue Specificity:
Highest levels in heart, placenta, lung, skeletal muscle, brain, liver, pancreas, kidney.

Post-translational modifications:
Autophosphorylated. Autophosphorylation may play a critical role in the regulation of GRK5 kinase activity.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
Contains 1 RGS domain.

Database links:
UniProtKB/Swiss-Prot: P34947.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 日本四虎影院 | 久久免费视频播放 | 欧产日产国产蜜网站 | 探花论坛| 高清毛片在线观看 | 国产亚洲欧美另类在线第1页 | 国产免费一级淫片a级中文 www.avtvtv.com新网址 | 国内精品伊人久久久久影院对白 | 免费又色又爽又黄的舒服软件 | 亚洲最新av无码中文字幕一区 | 欧美高清成人 | 日韩中文字幕区 | 国产无套露脸视频在线观看 | 久久精品爱看无码免费视频 | 久久精品国产一区二区三区不卡 | 国产亚洲精品视觉盛宴 | 99视频精品免费 | 久久久大尺度 | 亂倫近親相姦中文字幕视频 | 99久久免费国产精品四虎 | 免费超碰 | 九九精品视频在线观看 | 亚洲欧美日本国产综合 | 国产成人亚洲综合a∨婷婷图片 | 性XXXX中国HD | 国产精品美女久久久久久久久久久 | 酒店大战丝袜高跟鞋人妻 | 国产精品精品久久久 | 国产真实迷奷系列 | 调教女m屁股撅虐调教 | 永久免费av在线观看 | 青热久思思 | xxxxwwww在线观看 | 久久久久99精品久久久久 | 无码中文日本精品一区 | 色狠狠一区二区三区香蕉 | 欧美日韩国产成人在线91 | 91大神一区二区三区在线观看 | 在线国产福利 | 亚洲国产精品成人 | 扒开双腿疯狂进出爽爽爽动态图 |