超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
欧美射射射,亚洲精品国产第一区二区尤物 ,aaa欧美
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-GRK5/BF555 Conjugated antibody (bs-7540R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7540R-BF555
英文名稱 Rabbit Anti-GRK5/BF555 Conjugated antibody
中文名稱 BF555標記的G蛋白偶聯受體激酶5抗體
別    名 G protein coupled receptor kinase 5; G protein coupled receptor kinase GRK5; G protein-coupled receptor kinase 5; G protein-coupled receptor kinase GRK5; GPRK5; GRK5; GRK5_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  信號轉導  轉錄調節因子  激酶和磷酸酶  G蛋白偶聯受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GRK5
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008].

Function:
Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).

Subunit:
Interacts with ST13 (via the C-terminus 303-319 AA). Interacts with TP53/p53. Interacts with HTR4 (via C-terminus 330-346 AA); this interaction is promoted by 5-HT (serotonin). Interacts with HDAC5.

Subcellular Location:
Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion.

Tissue Specificity:
Highest levels in heart, placenta, lung, skeletal muscle, brain, liver, pancreas, kidney.

Post-translational modifications:
Autophosphorylated. Autophosphorylation may play a critical role in the regulation of GRK5 kinase activity.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
Contains 1 RGS domain.

Database links:
UniProtKB/Swiss-Prot: P34947.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 扒开双腿疯狂进出爽爽爽动态图 | 国产在线看片无码不卡 | 伊人中文字幕无码专区 | 波多野结衣中文字幕在线视频 | 免费黄色网页在线观看 | 狠狠躁夜夜躁人人爽超碰女h | 国产精品一区二区久久精品爱涩 | 一本久道在线视频 | 国产无遮挡裸体美女视频 | 97在线看| 精品人妻系列无码人妻免费视频 | 黑人中文字幕一区二区三区 | 色欲综合视频天天天 | 国模精品一区二区三区色天香 | 亚洲精品拍拍央视网出文 | 一区二区小视频 | 精品无人区一线二线三线区别 | 91精品久久久久久久久久久 | 天天插狠狠干 | 欧美美乳视频网站在线观看 | 亚洲xxxxx| 91新网址| 春色校园亚洲愉拍自拍 | 特级无码A级毛片特黄 | 国产精品第页 | 天天添天天操 | 国产亚洲av片在线观看18女人 | 久久久国产打桩机 | 国产人无码a在线西瓜影音 A级毛片高清免费视频在线播放 | 国产精品无码日韩字幕资不卡 | 日本50岁丰满熟妇xxxx | 免费精品自在久久 | 久久一区二区三区国产精品 | 亚洲AV色香蕉一区二区三区 | 99久热这里只有精品视频免费观看 | 香蕉超碰| 欧美亚洲视频一区二区 | 特黄把女人弄爽a片 | 国产精品久久久久久久久侵犯 | 久久久精品成人免费视频 | 天堂av一区二区 |