超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
久久久91精品国产一区二区精品,成人亚洲a片v一区二区三区,日本无线免费视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-IRS1/BF555 Conjugated antibody (bs-0172R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0172R-BF555
英文名稱 Rabbit Anti-IRS1/BF555 Conjugated antibody
中文名稱 BF555標記的胰島素受體底物-1抗體
別    名 HIRS 1; HIRS1; Insulin Receptor Substrate 1; IRS-1; IRS 1; IRS1; OTTHUMP00000164234; IRS1_HUMAN.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 細胞生物  神經生物學  信號轉導  細胞凋亡  糖尿病  內分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Pig,  (predicted: Chicken, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 137kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from rat IRS-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS1 degradation pathways are not well understood. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS1, 2, 3 and 4, with IRS1 being widely expressed.

Function:
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Subunit:
Interacts with UBTF and PIK3CA. Interacts (via phosphorylated YXXM motifs) with PIK3R1. Interacts with ROCK1 and FER. Interacts (via PH domain) with PHIP. Interacts with GRB2. Interacts with SOCS7. Interacts (via IRS-type PTB domain) with IGF1R and INSR (via the tyrosine-phosphorylated NPXY motif). Interacts with ALK.

Subcellular Location:
IRS1 is predominantly found in the cytoplasm. Nuclear localization may occur in some cell types and under specific stimuli.

Post-translational modifications:
Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor.
Phosphorylation of Tyr-896 is required for GRB2-binding.

DISEASE:
Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM)

Similarity:
Contains 1 IRS-type PTB domain.
Contains 1 PH domain.

Database links:

Entrez Gene: 3667 Human

Entrez Gene: 16367 Mouse

Entrez Gene: 25467 Rat

Omim: 147545 Human

SwissProt: P35568 Human

SwissProt: P35569 Mouse

SwissProt: P35570 Rat

Unigene: 471508 Human

Unigene: 4952 Mouse

Unigene: 10476 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信號傳導(Signaling Intermediates)
胰島素受體底物-1是細胞中分子量為165-185kDa的磷蛋白,胰島素受體的內源性底物。經胰島素刺激后其酪氨酸殘基被磷酸化。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 模特三点尽露私拍在线 | www.俺去了| 91久久夜色精品国产按摩 | 一区二区三区免费视频网站 | 日日夜夜爱爱 | 久久96久久96精品免视看 | 日韩拔插拔插 | 5566日本婷婷色中文字幕 | 色诱久久av | 日韩精品人妻系列无码专区 | 日产精品一区二区 | 男女视频一区二区 | 国产91网站在线观看 | 亚洲色图网友自拍 | 亚洲a免费| 四虎国产精品永久在线观看 | 色青青草原桃花久久综合 | 欧美精品九九99久久 | 久久69国产精品久久69软件 | 国内精品美女A∨在线播放 国产做a爱一级久久 | 一区二区免费高清观看国产丝瓜 | 日本高清v| 日本高清无卡码一区二区久久 | 国产亚洲人成网站在线观看 | 亚洲欧美激情视频 | 欧美黄色性视频 | a级黄色毛片三 | 国产精品美女久久久久av毛片 | 四虎影视在线视频大全免费观看 | 扒丝袜网www午夜一区二区三区 | 久久久久国产一区二区三区不卡 | caoporn最新地址 | 中文字幕av免费在线观看 | 国产在线视频2019最新视频 | 成A人影片免费观看日本 | 亚洲网站在线观看视频 | 亚洲日韩成人无码私人影院 | 黑人大荫道BBWBBB高潮潮喷 | 曰本一区二区 | 成人黄色免费大片 | 色播影院私人影院免费 |