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Rabbit Anti-Lingo-1/AP Conjugated antibody (bs-1177R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1177R-AP
英文名稱 Rabbit Anti-Lingo-1/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的Nogo受體反應蛋白抗體
別    名 FLJ14594; LERN 1; LERN1; Lingo1; Leucine rich repeat and Ig domain containing 1; Leucine rich repeat neuronal protein 1; Leucine rich repeat neuronal protein 6A; Leucine-rich repeat neuronal 6A; Lingo 1; LRR and Ig domain-containing Nogo Receptor interating protein; Lrrn 6a; Lrrn6a; Lrrn6a protein; MGC17422; Nogo Receptor interacting protein; UNQ201.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 發育生物學  神經生物學  信號轉導  通道蛋白  細胞膜受體  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產品應用 WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Lingo-1 (521-620aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
LINGO-1 (LRR and Ig domain-containing Nogo Receptor interating protein) is a nervous system-specific LRR-Ig-containing protein with an important role in CNS biology. LINGO-1 was discovered in a sequence database search for human SLIT homologs that were selectively expressed in the brain. LINGO-1 is a transmembrane protein that is a component of the Nogo-66 receptor complex. It binds NgR1 and p75 and is an additional functional componenet of the NgR1/p75 signaling complex.

Function:
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.

Subunit:
Homotetramer. Forms ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Tissue Specificity:
Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.

Post-translational modifications:
N-glycosylated. Contains predominantly high-mannose glycans.

Similarity:
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 11 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
Contains 1 LRRNT domain

Database links:

Entrez Gene: 415344 Chicken

Entrez Gene: 84894 Human

Entrez Gene: 235402 Mouse

Entrez Gene: 315691 Rat

Omim: 609791 Human

SwissProt: Q50L44 Chicken

SwissProt: Q6NUK3 Human

SwissProt: Q96FE5 Human

SwissProt: Q9D1T0 Mouse

Unigene: 656765 Human

Unigene: 246605 Mouse

Unigene: 20269 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神經生物學相關蛋白(Neurobiology)
LINGO-1是一種體內體外少突膠質細胞(Oligodendrocyte)分化和髓鞘(myelination)的負調控因子,神經元上的LINGO-1被證明參與調節中樞神經再生的抑制信號,而少突膠質細胞表達的LINGO-1分子參與負調節少突膠質細胞的髓鞘化過程,是一種體內體外少突膠質細胞(Oligodendrocyte)分化和髓鞘(myelination)的負調控因子。
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