超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
欧美久久久久久久久久久,中文字幕在线网站,无码少妇一区二区三区视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Lpin1 protein/HRP Conjugated antibody (bs-0760R-HRP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0760R-HRP
英文名稱 Rabbit Anti-Lpin1 protein/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標記的Lpin1 抗體
別    名 EC=3.1.3.4; KIAA0188; LPIN1; PAP1; Phosphatidate phosphatase LPIN1; HDLCQ11; Lipase; LIPD; LIPOPROTEIN LIPASE; Lipoprotein lipase 1; LPL; MGC137861; MGC93586; LPIN1_MOUSE.   
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  信號轉導  內分泌病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse,  (predicted: Rat, )
產品應用 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 102kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse Lpin 1 protein
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism.
LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.

Function:
Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol.

Subunit:
Interacts (via LXXIL motif) with PPARA. Interacts with PPARGC1A. Interaction with PPARA and PPARGC1A leads to the formation of a complex that modulates gene transcription. Interacts with MEF2C.

Subcellular Location:
soform 1: Mitochondrion outer membrane. Cytoplasm. Nucleus membrane. Note=Recruited at the mitochondrion outer membrane following phosphatidic acid formation mediated by PLD6. In neuronals cells, isoform 1 is exclusively cytoplasmic. In 3T3-L1 pre-adipocytes, it primarily located in the cytoplasm.
Isoform 2: Nucleus. Cytoplasm. Endoplasmic reticulum membrane. Note=Nuclear localization requires both CNEP1R1 and CTDNEP1. In neuronals cells, localized in both the cytoplasm and the nucleus. In 3T3-L1 pre-adipocytes, it is predominantly nuclear.

Tissue Specificity:
Specifically expressed in skeletal muscle. Also expressed prominently in adipose tissue, and testis. Lower expression also detected in kidney, lung, brain and liver. Isoform 1 is the predominant isoform in the liver. Isoform 2 is the major form in the brain.

Post-translational modifications:
Phosphorylated at multiple sites in response to insulin. Phosphorylation is controlled by the mTOR signaling pathway. Phosphorylation is decreased by epinephrine. Phosphorylation may not directly affect the catalytic activity but may regulate the localization. Dephosphorylated by the CTDNEP1-CNEP1R1 complex.
Sumoylation is important in brain and is marginal in other tissues. Sumoylation facilitates nuclear localization of isoform 2 in neuronals cells and its transcriptional coactivator activity.

DISEASE:
Note=Defects in Lpin1 are the cause of the fatty liver dystrophy phenotype (fld). Fld mutant mices are characterized by neonatal fatty liver and hypertriglyceridemia that resolve at weaning, and neuropathy affecting peripheral nerve in adulthood. Adipose tissue deficiency, glucose intolerance and increased susceptibility to atherosclerosis are associated with this mutation too. Two independent mutant alleles are characterized in this phenotype, fld and fld2j.

Similarity:
Belongs to the lipin family.

Database links:

Entrez Gene: 23175 Human

Entrez Gene: 14245 Mouse

Entrez Gene: 313977 Rat

Omim: 605518 Human

SwissProt: Q14693 Human

SwissProt: Q91ZP3 Mouse

Unigene: 467740 Human

Unigene: 153625 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Lpin1 protein主要用于脂酯代謝異常、胰島素抵抗及肥胖方面的研究。
該蛋白在肝,肺,腎,胎盤,脾臟,胸腺,淋巴結,前列腺,睪丸,小腸和大腸等組織中都有程度不同的表達。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 免费观看欧美日韩亚洲 | 欧美性猛交xxxx乱大交俱乐部 | 大肉大捧一进一出好爽视色大师 | 色999久久久精品人人澡69 | 久草com | 国产卡一卡二卡乱码 | 日本高清wwwff174 | 国产高清在线精品一区 | 亚洲色大成网站WWW永久 | 亚洲国产精品久久久久久久 | 日本免费一二三区中文 | 福利社一区| 在线观看中出 | 亚洲热妇无码播放aV另类 | 国产色诱视频在线播放网站 | 国产乱码精品一品二品 | 国产精品流白浆在线观看 | 新国产三级在线观看播放 | 成人精品av一区二区三区网站 | 拍拍拍av| 成人18在线观看 | 欧美午夜精品久久久久久人妖 | 亚洲一区二区三区四区免费观看 | 亚日韩一区 | 亚洲天堂一区二区三区四区 | 国产免费一区二区三区播放 | 粗大的内捧猛烈进出的视频免费 | 成年女人18级毛片毛片免费 | 国产一区免费观看 | 亚洲中文日产2021 | 国模两腿玉门打开图无码 | 黄色片哪里可以看 | 国产乱对白刺激视频户外 | 国产一国产二国产三国产四国产五 | 亚洲激精日韩激精欧美精品 | 99久久免费精品国产男女高不卡 | 国产精品美女久久久久久久久久久 | 中国一级毛片免费观看 | 国内精品美女A∨在线播放 国产做a爱一级久久 | 荷兰一级片 | 中文字幕无码人妻丝袜 |