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Rabbit Anti-Septin 8/Gold Conjugated antibody (bs-6907R-Gold)
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說 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-6907R-Gold
英文名稱 Rabbit Anti-Septin 8/Gold Conjugated antibody
中文名稱 膠體金標記的細胞分化蛋白SEPT8抗體
別    名 Nkrf; RCG53214, isoform CRA_d; SEP2; SEP 2; SEP2; SEPT 8; SEPT8; SEPT-8; Septin8; Septin 8; Septin-8; SEPT8_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul(10nm  15nm  35nm
研究領域 細胞生物  神經(jīng)生物學  細胞周期蛋白  細菌及病毒  細胞分化  細胞骨架  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Cow, )
產(chǎn)品應用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 53kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SEPT8
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. [provided by RefSeq, Jun 2012].

Function:
Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in platelet secretion.

Subunit:
Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with CDK14, SEPT4, SEPT5 and SEPT7.

Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton. Note=In platelets, found in areas surrounding alpha-granules.

Tissue Specificity:
Widely expressed, including in brain, heart and platelets; most abundant in aorta. Isoform 2 is expressed at low levels in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 1 and 3 are highly expressed in specific brain areas, such as occipital pole, frontal lobe, temporal lobe and putamen. Isoform 2 is highly expressed in prostate, testis and ovary. Isoform 1 and isoform 3 are expressed at low levels in prostate, testis and ovary.

Similarity:
Belongs to the septin family.

Database links:
UniProtKB/Swiss-Prot: Q92599.4

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SEPTIN(SEPT)家族是細胞骨架蛋白的一種,具有GTPase的活性。經(jīng)研究發(fā)現(xiàn),SEPT參與細胞的分裂、細胞膜的運輸以及構(gòu)成細胞骨架。
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