超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
日本在线成人一区二区,奇米影视7777狠狠狠狠色,午夜看片福利在线
Rabbit Anti-BRD7/Cy5 Conjugated antibody (bs-7779R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-7779R-Cy5
英文名稱 Rabbit Anti-BRD7/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的鼻咽癌相關(guān)轉(zhuǎn)錄調(diào)節(jié)蛋白抗體
別    名 75 kDa bromodomain protein; BP75; BRD 7; BRD7; BRD7_HUMAN; Bromodomain containing 7; bromodomain containing protein 7; Bromodomain-containing protein 7; CELTIX 1; CELTIX1; NAG4; Protein CELTIX-1.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 74kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BRD7
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants.

Function:
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.

Subunit:
Interacts with TRIM24, PTPN13 and DVL1. Identified in a complex with SMARCA4/BRG1, SMARCC1/BAF155, SMARCE1/BAF57, DPF2/BAF45D and ARID2, subunits of the SWI/SNF-B (PBAF) chromatin remodeling complex (By similarity). Interacts with IRF2 and HNRPUL1. Interacts (via N-terminus) with TP53. Interacts (via C-terminus) with EP300. Interacts with BRCA1. Interacts (via bromo domain) with histone H3 (via N-terminus) acetylated at 'Lys-14' (H3K14ac). Has low affinity for histone H3 acetylated at 'Lys-9' (H3K9ac). Has the highest affinity for histone H3 that is acetylated both at 'Lys-9' (H3K9ac) and at 'Lys-14' (H3K14ac). Has very low affinity for non-acetylated histone H3. Interacts (via bromo domain) with histone H4 (via N-terminus) acetylated at 'Lys-8' (H3K8ac) (in vitro).

Subcellular Location:
Isoform 2: Nucleus.

Similarity:
Contains 1 bromo domain.

Database links:
UniProtKB/Swiss-Prot: Q9NPI1.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

BRD7可能參與了基因轉(zhuǎn)錄調(diào)控,是一個(gè)核轉(zhuǎn)錄調(diào)節(jié)蛋白。經(jīng)研究發(fā)現(xiàn)BRD7可能是通過Ras/MEK/ERK和Rb/E2F兩條通路影響細(xì)胞周期的進(jìn)程,使細(xì)胞停滯于G0/G1期,BRD7具有阻止細(xì)胞周期進(jìn)程的作用。BRD7蛋白尤其是在鼻咽癌的發(fā)病過程中發(fā)揮了十分重要作用,BRD7基因的過表達(dá)可通過調(diào)節(jié)MAPK及Wnt信號通路抑制鼻咽癌的生長,并將鼻咽癌阻滯在G1/S期。
版權(quán)所有 2004-2026 www.ggggww.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
主站蜘蛛池模板: 国产伦一区二区三区免费 | 无遮挡3d黄肉动漫午夜 | 久久久精品国产一区二区 | 欧美一级淫片aaaa | 92少妇午夜福利视频在线 | 人妻有码中文字幕在线 | 亚洲第一综合区 | 亚洲va在线视频 | 插插插操操操 | www.av在线| 人人爽人人澡人人人妻 | 女人和公猪交内射网站 | 精品午夜一区二区 | 日本三级黄色网址 | 人人妻人人澡人人爽国产 | 村女艳史理伦一及毛片 | 国产伦人人人人人人性 | 国内外成人在线视频 | 亚洲欧洲∨国产一区二区三区 | 91精品国产色综合久久 | 久久久亚洲男人的天堂一区二区三区 | 午夜天堂成人欧美www无码 | 天天成人| 久久99精品久久久久久无毒不卡8 | 性男女做视频观看网站 | 99精品视频免费热播在线观看 | 久久精品亚洲精品国产欧美 | 国产成人精品免费视频大全 | 精品国产乱码久久久久久影片 | 日韩精品久久无码人妻中文字幕 | 亚洲AV无码乱码在线观看看 | 中文字幕佐山爱一区二区 | 人人草人人舔 | 黑人巨大无码中文字幕无码 | 野花高清在线观看免费8 | 蜜桃国精产品二三三区视频 | 亚洲精品拍拍央视网出文 | 99久久久精品免费观看国产 | 在线国产福利 | 息与子五十路中文字幕 | 精品国产一区二区三区av性色 |