超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
日韩黄色一级片,久久久久,污片在线观看视频
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-BRD7/PE Conjugated antibody (bs-7779R-PE)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-7779R-PE
英文名稱 Rabbit Anti-BRD7/PE Conjugated antibody
中文名稱 PE標記的鼻咽癌相關轉錄調節蛋白抗體
別    名 75 kDa bromodomain protein; BP75; BRD 7; BRD7; BRD7_HUMAN; Bromodomain containing 7; bromodomain containing protein 7; Bromodomain-containing protein 7; CELTIX 1; CELTIX1; NAG4; Protein CELTIX-1.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  信號轉導  細胞周期蛋白  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 74kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human BRD7
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants.

Function:
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.

Subunit:
Interacts with TRIM24, PTPN13 and DVL1. Identified in a complex with SMARCA4/BRG1, SMARCC1/BAF155, SMARCE1/BAF57, DPF2/BAF45D and ARID2, subunits of the SWI/SNF-B (PBAF) chromatin remodeling complex (By similarity). Interacts with IRF2 and HNRPUL1. Interacts (via N-terminus) with TP53. Interacts (via C-terminus) with EP300. Interacts with BRCA1. Interacts (via bromo domain) with histone H3 (via N-terminus) acetylated at 'Lys-14' (H3K14ac). Has low affinity for histone H3 acetylated at 'Lys-9' (H3K9ac). Has the highest affinity for histone H3 that is acetylated both at 'Lys-9' (H3K9ac) and at 'Lys-14' (H3K14ac). Has very low affinity for non-acetylated histone H3. Interacts (via bromo domain) with histone H4 (via N-terminus) acetylated at 'Lys-8' (H3K8ac) (in vitro).

Subcellular Location:
Isoform 2: Nucleus.

Similarity:
Contains 1 bromo domain.

Database links:
UniProtKB/Swiss-Prot: Q9NPI1.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

BRD7可能參與了基因轉錄調控,是一個核轉錄調節蛋白。經研究發現BRD7可能是通過Ras/MEK/ERK和Rb/E2F兩條通路影響細胞周期的進程,使細胞停滯于G0/G1期,BRD7具有阻止細胞周期進程的作用。BRD7蛋白尤其是在鼻咽癌的發病過程中發揮了十分重要作用,BRD7基因的過表達可通過調節MAPK及Wnt信號通路抑制鼻咽癌的生長,并將鼻咽癌阻滯在G1/S期。
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 18禁美女裸体网站无遮挡 | 国产精品一区二区在线播放 | 麻豆爱爱| 国产成人精选在线观看不卡 | 穿书自救指南2樱花动漫免费观看 | 无码熟妇人妻AV在线影片最多 | 色多多在线打开 | 国产精品国产三级国产在线观什 | 国产精品探花一区二区在线观看 | 欧美日本成人 | 国产精华液一线二线三线区别 | 久久精品国产www456c0m | 欧美日韩国产一区二区三区在线 | 涩涩网站在线观看 | 亚洲黄一区二区三区 | av中文字幕亚洲 | 久操av在线播放 | 久久一区二区三区精华液 | 欧美xxxav| 韩日精品一区 | 一级欧美一级日韩片免费观看 | 96精品成人无码A片观看金桔 | 黄色视频毛片 | 国产午夜啪啪 | 饥渴的少妇毛片免费视频 | 最新免费中文字幕 | 午夜视频在线观看免费视频 | 亚洲成人一区在线 | 欧美一级黄色影片 | 精选的2019中文字幕视频 | 日本男人女人做爰视频男人 | 日本熟妇无码色视频在线观看 | a级免费毛片 | 欧美无乱码久久久免费午夜一区 | 国产一区二区三区黄视频 | 看日本毛片 | 国产在线播放av | 国内av在线 | 亚洲无av在线中文字幕 | 中文字幕+乱码+中文乱 | 久久久久久久久久美女 |