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Rabbit Anti-PSF2/PE-Cy5.5 Conjugated antibody (bs-7824R-PE-Cy5.5)
訂購(gòu)熱線:400-901-9800
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訂購(gòu)QQ:  400-901-9800
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說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-7824R-PE-Cy5.5
英文名稱 Rabbit Anti-PSF2/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的PSF2蛋白抗體
別    名 GINS complex subunit 2; GINS2; HSPC037; PSF2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  細(xì)胞周期蛋白  細(xì)胞分化  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 21kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PSF2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The GINS complex is composed of four subunits, encoded by SLD5, PSF1, PSF2, and PSF3. In S. cerevisiae, it was first identified by genetic and biochemical methods to determine factors interacting with Sld5p. Genetic interactions between these four genes also suggest that they act together. The GINS complex was independently isolated in a large scale screen for cell cycle defects. A similar complex is found in Xenopus and has a ring-like structure. In yeast, all four genes are essential and cells defective in SLD5, PSF1, or PSF2 are impaired in their ability to replicate DNA. The complex localizes to origins of DNA replication and Sld5p was previously implicated as functioning in DNA replication due to its genetic interaction with DPB11. Additional genetic and biochemical interactions of the GINS complex with Dpb11p, Dpb2p, and Sld3p suggest that it functions in some way at the replication fork during DNA synthesis.

Function:
The GINS complex plays an essential role in theinitiation of DNA replication, and progression of DNA replicationforks. GINS complex seems to bind preferentially to single-strandedDNA.

Subunit:
Component of the GINS complex which is a heterotetramerof GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex withGINS3. GINS complex interacts with DNA primase in vitro.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the GINS2/PSF2 family.

Database links:

Entrez Gene: 415824 Chicken

Entrez Gene: 609436 Dog

Entrez Gene: 51659 Human

Entrez Gene: 272551 Mouse

Entrez Gene: 292058 Rat

Entrez Gene: 444053 Xenopus laevis

Entrez Gene: 554146 Zebrafish

Omim: 610609 Human

SwissProt: Q9Y248 Human

SwissProt: Q9D600 Mouse

SwissProt: Q7ZT46 Xenopus laevis

Unigene: 433180 Human

Unigene: 275910 Mouse

Unigene: 3786 Xenopus laevis



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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