超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
免费观看一级视频,12av在线,欧美日产国产精品
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Lin-28B/FITC Conjugated antibody (bs-6446R-FITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6446R-FITC
英文名稱 Rabbit Anti-Lin-28B/FITC Conjugated antibody
中文名稱 FITC標記的RNA結合蛋白LIN28B抗體
別    名 Lin28B; CSDD 2; CSDD2; FLJ16517; Lin 28 homolog B (C. elegans); Lin 28.2; Lin-28B; LIN28B; LN28B_HUMAN; Protein lin-28 homolog B.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Lin-28B
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.

Function:
Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.

Subunit:
Interacts with ZCCHC11/TUT4.

Subcellular Location:
Cytoplasm. Nucleus. Predominantly cytoplasmic at G1 phase, accumulates in the nucleus in S and G2 phases. The frequency of nuclear localization in S and in G2 phases is 60% and 30%, respectively.

Tissue Specificity:
High expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC). Isoform 1 is only detected in moderately and poorly differentiated HCC tissues and placenta (at protein level). Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues (at protein level).

Similarity:
Belongs to the lin-28 family.
Contains 2 CCHC-type zinc fingers.
Contains 1 CSD (cold-shock) domain.

Database links:

Entrez Gene: 389421 Human

Entrez Gene: 380669 Mouse

Omim: 611044 Human

SwissProt: Q6ZN17 Human

SwissProt: Q45KJ6 Mouse

Unigene: 23616 Human

Unigene: 440328 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 满天神佛国语免费观看 | 不卡的在线视频 | 国产美女网站视频 | 五月天婷婷导航 | 国内揄拍国内精品对白 | 在线免费观看福利 | 中文字幕被公侵犯的漂亮人妻 | 日本日本熟妇中文在线视频 | 人人99 | 久久久99精品 | 自拍日韩亚洲一区在线 | 国产精品99精品无码视亚 | 一二三四五社区在线高清观看 | 在线观看日本欧美 | 欧美亚洲日韩在线综合 | 亚洲国产精品日韩av不卡在线 | 开心五月激情中文在线 | 日本无码潮喷A片无码高潮 欧美变态另类人妖 | 91看片免费在线观看 | 国产精品18久久久不卡最新章节 | 国产做爰又粗又大的视频 | 无码视频免费一区二区 | 日本一道aⅴ不卡免费播放 www.黄色免费网站 | 一本岛道一二三不卡区 | 亚洲欧美乱综合图片区小说区 | 老司机午夜在线视频 | 精品91在线 | 女高中生第一次破苞av | 午夜无人区免费网站 | 国产亚洲影视在线视频播放 | 国产精品俺来也在线观看 | 亚洲国产aa | 中文字幕色一区二区 | 女18一级大黄毛片免费女人 | 国产美女一级做受老师 | av在线中文播放 | 国产美女在线精品 | 日本一区二区色 | 射久久久 | YY6080午夜福利理论中文 | 日韩av一二三区 |