超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
在线日韩AV永久免费观看,精品国产31久久久久久,成人免费视频www在线观看我
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Lin-28B/PE-Cy3 Conjugated antibody (bs-6446R-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-6446R-PE-Cy3
英文名稱 Rabbit Anti-Lin-28B/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的RNA結合蛋白LIN28B抗體
別    名 Lin28B; CSDD 2; CSDD2; FLJ16517; Lin 28 homolog B (C. elegans); Lin 28.2; Lin-28B; LIN28B; LN28B_HUMAN; Protein lin-28 homolog B.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  免疫學  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Lin-28B
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.

Function:
Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.

Subunit:
Interacts with ZCCHC11/TUT4.

Subcellular Location:
Cytoplasm. Nucleus. Predominantly cytoplasmic at G1 phase, accumulates in the nucleus in S and G2 phases. The frequency of nuclear localization in S and in G2 phases is 60% and 30%, respectively.

Tissue Specificity:
High expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC). Isoform 1 is only detected in moderately and poorly differentiated HCC tissues and placenta (at protein level). Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues (at protein level).

Similarity:
Belongs to the lin-28 family.
Contains 2 CCHC-type zinc fingers.
Contains 1 CSD (cold-shock) domain.

Database links:

Entrez Gene: 389421 Human

Entrez Gene: 380669 Mouse

Omim: 611044 Human

SwissProt: Q6ZN17 Human

SwissProt: Q45KJ6 Mouse

Unigene: 23616 Human

Unigene: 440328 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 水蜜桃一区二免费 | 国产成人无码区免费内射一片色欲 | 亚洲成av人的天堂在线观看 | 91精品91久久久中77777老牛 | 九九九热精品 | 久久国产自偷自偷免费一区调 | 男变身成少妇h | 91精品国产爱久久丝袜脚 | 成人免费无码成人影院日韩 | 亚洲毛片无码专区亚洲乱 | 色欲AV亚洲情无码AV蜜桃 | 永久免费av无码不卡在线观看 | 中文字幕在线播放一区 | 四虎在线精品 | 亚洲福利一区 | 无码欧亚熟妇人妻AV在线外遇 | 久中文字幕 | 狠狠躁天天躁夜夜添人人 | 久久999精品久久久 h成人在线观看 | 精品毛片免费看 | 久草在线免费资源 | 精品国产91亚洲一区二区三区www | 欧美亚洲另类在线视频 | 国产在线视频2019最新视频 | 国产精品久久久久精女同 | 国产精品国产精品国产 | 四虎成人精品国产永久免费 | 亚洲av人人夜夜澡人人 | 好男人资源在线观看好 | 久久久精品精品 | 亚洲伦理 | 欧美熟妇的荡欲在线观看 | 91麻豆精品国产91久久久使用方法 | 亚洲色,天堂网 | 中文字幕一区二区三区色视频 | 国产精品久久久久久日本 | 东京热中文字幕aⅴ专区 | 黄色毛片av | 中国一及毛片 | 无码高潮又爽又黄A片 | 伊人色私人影院蜜桃va |