超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
国产精品日日夜夜,女人18毛片水最多,亚洲a毛片
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-SIP1/HRP Conjugated antibody (bs-9186R-HRP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-9186R-HRP
英文名稱 Rabbit Anti-SIP1/HRP Conjugated antibody
中文名稱 辣根過氧化物酶標記的Smad蛋白相互作用蛋白1抗體
別    名 Smad Interacting Protein 1 SIP 1; SIP1 SIP-1; Smad-interacting protein 1; SMADIP 1; SMADIP1; ZEB 2; ZEB2; ZEB2_HUMAN; Zfhx1b; ZFHX1B protein; Zfx1b; Zinc finger E box binding protein 2; Zinc finger E-box-binding homeobox 2; Zinc finger homeobox 1b; zinc finger homeobox protein 1; Zinc finger homeobox protein 1b.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  發育生物學  神經生物學  干細胞  細胞周期蛋白  轉錄調節因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Chicken, Dog, Horse, )
產品應用 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 136kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
SMAD regulates gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins. SIP1, for SMAD interacting protein 1, is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SIP1 contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1, also known as SMADIP1, ZFHX1B and ZEB2 (zinc finger E-box-binding protein 2), can be induced by TGF∫ treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease—all symptoms of HSCR.

Function:
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.

Subunit:
Binds activated SMAD1, activated SMAD2 and activated SMAD3; binding with SMAD4 is not detected (By similarity). Interacts with CBX4 and CTBP1.

Subcellular Location:
Nucleus.

Post-translational modifications:
Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.

DISEASE:
Defects in ZEB2 are the cause of Mowat-Wilson syndrome (MWIS) [MIM:235730]; also known as Hirschsprung disease-mental retardation syndrome. A complex developmental disorder characterized by mental retardation, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Some patients manifest Hirschsprung disease. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes.

Similarity:
Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
Contains 7 C2H2-type zinc fingers.
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 9839 Human

Entrez Gene: 24136 Mouse

Entrez Gene: 311071 Rat

Omim: 605802 Human

SwissProt: O60315 Human

SwissProt: Q9R0G7 Mouse

Unigene: 34871 Human

Unigene: 440702 Mouse

Unigene: 59710 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 大地网资源在线观看免费高清 | 78影视传媒有限公司 | 无码中出人妻中文字幕AV | 97无码免费人妻超级碰碰碰碰 | 国产精品视频成人 | 成人在线免费视频 | 国产一区三区四区 | 中国成人免费视频 | 日本噜噜噜 | 亚洲AV无码专区亚洲AV紧身裤 | 最近中文字幕第一页 | 亚洲AV无码片区一区二区三区 | 夜夜躁狠狠躁日日躁202 | 四虎网站| 一本久道中文字幕精品亚洲嫩 | 色网小说| 久久久久久久99精品免费观看 | 黄色片子免费 | 最近2019年日本中文免费字幕 | 国产乱人伦在线播放 | 欧美综合社区 | 无码日韩人妻AV一区 | 91视频导航 | 96精品成人无码A片观看金桔 | 97精品国产97久久久久久粉红 | 综合网中文字幕 | 国产精品二区三区 | 137大胆人体在线观看 | 国产玉足榨精视频在线 | 国产自在自线午夜精品 | 欧美性色黄大片 | 蜜桃AV蜜臀AV色欲AV麻 | 国产一区二区网站 | 狂猛欧美激情性XXXX大豆行情 | 84pao国产成人高清在线 | 国产精品私密保健会所 | 免费做人爱高潮1000视频 | 亚洲444KKKK在线观看无码 | 绯色av一区二区三区免费看 | 超碰超级在线免费观看 | 久久久亚洲一区二区三区 |