超碰97自拍_久久99久久98精品免观看软件_在线亚洲一区_九九视频这里只有精品_国产精品一区二区欧美视频_精品国产区一区

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
18久久,亚洲国产另类久久久精品小说,国产综合无码一区二区辣椒
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-SIP1/BF647 Conjugated antibody (bs-9186R-BF647)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-9186R-BF647
英文名稱 Rabbit Anti-SIP1/BF647 Conjugated antibody
中文名稱 BF647標記的Smad蛋白相互作用蛋白1抗體
別    名 Smad Interacting Protein 1 SIP 1; SIP1 SIP-1; Smad-interacting protein 1; SMADIP 1; SMADIP1; ZEB 2; ZEB2; ZEB2_HUMAN; Zfhx1b; ZFHX1B protein; Zfx1b; Zinc finger E box binding protein 2; Zinc finger E-box-binding homeobox 2; Zinc finger homeobox 1b; zinc finger homeobox protein 1; Zinc finger homeobox protein 1b.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 心血管  細胞生物  發育生物學  神經生物學  干細胞  細胞周期蛋白  轉錄調節因子  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Chicken, Dog, Horse, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 136kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SIP1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
SMAD regulates gene expression by interacting with different classes of transcription factors including DNA-binding multi-zinc finger proteins. SIP1, for SMAD interacting protein 1, is a member of the delta-EF1/Zfh1 family of 2-handed zinc finger/homeodomain proteins. SIP1 contains a SMAD-binding domain, a homeodomain and two clusters of zinc fingers on the N- and C-termini. SIP1, also known as SMADIP1, ZFHX1B and ZEB2 (zinc finger E-box-binding protein 2), can be induced by TGF∫ treatment. SIP1 plays a crucial role in normal embryonic development of neural structures and the neural crest. The human SIP1 gene maps to chromosome 2q22. Mutations in the SIP1 gene cause a form of Hirschsprung disease (HSCR). Patients with SIP1 mutations show mental retardation, delayed motor development, epilepsy, microcephaly, distinct facial features and/or congenital heart disease—all symptoms of HSCR.

Function:
Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin.

Subunit:
Binds activated SMAD1, activated SMAD2 and activated SMAD3; binding with SMAD4 is not detected (By similarity). Interacts with CBX4 and CTBP1.

Subcellular Location:
Nucleus.

Post-translational modifications:
Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity.

DISEASE:
Defects in ZEB2 are the cause of Mowat-Wilson syndrome (MWIS) [MIM:235730]; also known as Hirschsprung disease-mental retardation syndrome. A complex developmental disorder characterized by mental retardation, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Some patients manifest Hirschsprung disease. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes.

Similarity:
Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
Contains 7 C2H2-type zinc fingers.
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 9839 Human

Entrez Gene: 24136 Mouse

Entrez Gene: 311071 Rat

Omim: 605802 Human

SwissProt: O60315 Human

SwissProt: Q9R0G7 Mouse

Unigene: 34871 Human

Unigene: 440702 Mouse

Unigene: 59710 Rat




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.ggggww.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
主站蜘蛛池模板: 日韩成人av片 | 91精品无码一区二区 | 麻豆精品免费在线观看 | 两性午夜色视频免费网站 | 人妻系列AV无码专区 | www.五月天色 | 色视频在线观看免费 | 免费欧美视频 | 国内盗摄视频一区二区三区 | 国内黄色| 亚洲美女一级毛片 | 成人无码AV一区二区三区 | 欧美日韩久久 | 日韩一区免费在线观看 | 无码精品AV久久久奶水小说 | 久久人人爽人人爽人人片av超碰 | 中文字幕乱码久久午夜 | 午夜一区欧美二区高清三区 | 日日夜夜添 | 精品成人一区二区 | 99久久99久久久精品棕色圆 | 天天插狠狠干 | 日本少妇ⅹxxhd第一次 | 日韩在线观看一区 | 国产gv在线观看受被做哭 | 国产短视频在线观看 | 高清国产AV一区二区三区 | 国产精品久久久久久无码人妻 | 久久久高清免费视频 | 亚洲午夜精品A片一区二区三区 | 亚洲色图欧美自拍 | www.久久com| 亂倫近親相姦中文字幕视频 | 玖玖精品一区 | 日本三级无码中文字幕DVD | 爆乳一区二区三区无码 | 中国一级毛片免费观看 | 亚洲日本欧美天堂在线手机版 | 一本色道久久综合狠狠躁的推荐 | 尤物亚洲AV无码精品色午夜 | 日本一区二区三区网站 |